Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1313908..1314563 Replicon chromosome
Accession NZ_CP033364
Organism Mesorhizobium sp. NZP2234

Toxin (Protein)


Gene name vapC Uniprot ID A0A6M7VJD6
Locus tag EB230_RS06365 Protein ID WP_065005498.1
Coordinates 1313908..1314309 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0Q8KJP8
Locus tag EB230_RS06370 Protein ID WP_056575098.1
Coordinates 1314309..1314563 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB230_RS06345 1309343..1310377 - 1035 WP_056575085.1 aldo/keto reductase -
EB230_RS06350 1310433..1311614 - 1182 WP_172371859.1 MFS transporter -
EB230_RS06355 1311754..1312662 + 909 WP_172371861.1 LysR family transcriptional regulator -
EB230_RS06360 1312710..1313759 - 1050 WP_172371863.1 aldo/keto reductase -
EB230_RS06365 1313908..1314309 - 402 WP_065005498.1 type II toxin-antitoxin system VapC family toxin Toxin
EB230_RS06370 1314309..1314563 - 255 WP_056575098.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EB230_RS06375 1314643..1315305 - 663 WP_056575101.1 YggS family pyridoxal phosphate-dependent enzyme -
EB230_RS06380 1315462..1318086 + 2625 WP_065005499.1 leucine--tRNA ligase -
EB230_RS06385 1318073..1318651 + 579 WP_172371865.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1262108..1338160 76052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14941.09 Da        Isoelectric Point: 5.2325

>T113545 WP_065005498.1 NZ_CP033364:c1314309-1313908 [Mesorhizobium sp. NZP2234]
MYLLDTNIVSDVQRRLPKPTEWLASVDPTSVSLSVITLGEIERGIIKLRKVDSEKATRLDLWLRELRRDNADRILAVTED
VALTWGRITARRTRGSADTLIAATALVHDLILVTRNVADFDDTGVTVFNPWDA

Download         Length: 402 bp

>T113545 NZ_CP033364:c1314309-1313908 [Mesorhizobium sp. NZP2234]
ATGTATCTGCTCGACACGAACATCGTTTCGGATGTGCAGAGGCGACTACCCAAGCCAACCGAATGGCTGGCTTCGGTGGA
TCCGACCTCGGTCAGCCTCAGCGTCATCACGCTTGGAGAGATCGAACGTGGGATCATCAAGCTACGCAAGGTCGACTCCG
AAAAGGCAACACGCCTCGATCTGTGGCTACGGGAGCTTCGGCGCGACAATGCCGATCGTATTCTCGCCGTCACGGAAGAT
GTCGCGTTAACTTGGGGCCGCATCACCGCCCGCCGTACACGAGGCAGCGCCGATACCCTCATCGCGGCTACCGCTCTTGT
CCATGATCTCATTCTTGTGACGCGCAATGTTGCCGACTTCGACGATACAGGCGTGACGGTGTTCAATCCCTGGGACGCCT
AA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9581.72 Da        Isoelectric Point: 5.1409

>AT113545 WP_056575098.1 NZ_CP033364:c1314563-1314309 [Mesorhizobium sp. NZP2234]
MNWHLQDAKNNFSKVVQRARSEGPQTVTLRGERAAVVLSAEDYDRLAGKKKSLAEYLLTGPVWDDDFAEEVSRRSETMIR
DVDL

Download         Length: 255 bp

>AT113545 NZ_CP033364:c1314563-1314309 [Mesorhizobium sp. NZP2234]
ATGAACTGGCACCTTCAGGACGCAAAGAACAATTTCTCCAAGGTGGTTCAGCGTGCGCGCAGCGAGGGACCGCAGACGGT
GACGTTGCGCGGCGAGCGCGCCGCAGTGGTGCTTTCCGCCGAGGATTACGACCGCCTGGCCGGAAAGAAGAAGTCGTTGG
CCGAATATCTTTTGACTGGTCCGGTTTGGGACGATGATTTCGCCGAAGAGGTCAGCCGCCGCTCGGAGACGATGATCCGG
GACGTCGATCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M7VJD6

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q8KJP8

References