Detailed information of TA system TA113539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2767507..2768102
• Replicon: chromosome
• Accession: NZ_CP033361
• Organism: Mesorhizobium erdmanii strain NZP2014

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EB233_RS13405
• Protein ID: WP_081294017.1
• Coordinates: 2767914..2768102 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A6M7UP54
• Locus tag: EB233_RS13400
• Protein ID: WP_064989088.1
• Coordinates: 2767507..2767908 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB233_RS13375	2762970..2764241	+	1272	WP_064989092.1	arsenite efflux MFS transporter ArsK	-
EB233_RS13380	2764248..2764694	+	447	WP_064989091.1	SRPBCC domain-containing protein	-
EB233_RS13385	2764720..2765565	-	846	WP_081294018.1	helix-turn-helix transcriptional regulator	-
EB233_RS13390	2765653..2766537	+	885	WP_064989090.1	SDR family oxidoreductase	-
EB233_RS13395	2766773..2767474	-	702	WP_064989089.1	RibD family protein	-
EB233_RS13400	2767507..2767908	-	402	WP_064989088.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EB233_RS13405	2767914..2768102	-	189	WP_081294017.1	type II toxin-antitoxin system HicA family toxin	Toxin
EB233_RS13410	2768463..2769410	+	948	WP_027052239.1	substrate-binding domain-containing protein	-
EB233_RS13415	2769629..2771227	+	1599	WP_081294016.1	sugar ABC transporter ATP-binding protein	-
EB233_RS13420	2771224..2772240	+	1017	WP_027052241.1	ABC transporter permease	-
EB233_RS13425	2772326..2772808	-	483	WP_208986325.1	flagellar basal body-associated protein FliL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7117.22 Da
• Isoelectric Point: 11.8350

>T113539 WP_081294017.1 NZ_CP033361:c2768102-2767914 [Mesorhizobium erdmanii]
MNSADIIRLLQADGWFEVARKGSHAQFKHRDKQGRVTVPHPRRDIPIGTLRSIEKQSGLKLR

Nucleotide

• Length: 189 bp

>T113539 NZ_CP033361:c2768102-2767914 [Mesorhizobium erdmanii]
ATGAATAGCGCTGATATTATCCGCCTGTTGCAAGCTGATGGTTGGTTCGAAGTTGCCCGAAAGGGCAGCCATGCACAATT
CAAACACCGCGATAAGCAAGGACGGGTCACTGTTCCTCATCCCAGGCGCGATATCCCAATAGGCACTCTGCGCAGCATCG
AAAAGCAATCTGGACTGAAACTGAGGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14169.98 Da
• Isoelectric Point: 4.3145

>AT113539 WP_064989088.1 NZ_CP033361:c2767908-2767507 [Mesorhizobium erdmanii]
MKQYIGLIHKDAGSDFGVSFPDFPGVITAGKDLDDARSMAEEALALHVEGLVEDGDAIPEPSSLEAVMADADNRDGVAIL
VAAKTDTRKAVRINVTLPDDVLRRIDAFAEAHGYTRSGFLAKAAEKVMDLEVA

Nucleotide

• Length: 402 bp

>AT113539 NZ_CP033361:c2767908-2767507 [Mesorhizobium erdmanii]
ATGAAGCAGTATATCGGACTTATCCATAAGGATGCCGGCAGCGACTTCGGTGTGTCCTTCCCTGATTTCCCAGGCGTGAT
TACCGCCGGCAAGGATCTGGATGACGCGCGGTCCATGGCAGAAGAGGCCCTCGCCCTCCACGTCGAAGGGCTGGTCGAGG
ATGGCGATGCTATTCCGGAGCCTTCGAGTCTGGAGGCTGTGATGGCGGACGCCGACAATCGTGACGGTGTTGCGATCTTG
GTCGCGGCCAAGACCGACACCAGGAAGGCAGTGCGTATCAACGTGACGTTGCCCGACGACGTCCTGCGGCGGATCGATGC
CTTTGCCGAAGCCCATGGCTATACTCGATCCGGGTTTCTCGCGAAGGCGGCTGAGAAAGTGATGGACCTCGAAGTGGCCT
GA

Structures

Antitoxin

• AlphaFold DB: A0A6M7UP54