Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2592981..2593633 Replicon chromosome
Accession NZ_CP033361
Organism Mesorhizobium erdmanii strain NZP2014

Toxin (Protein)


Gene name vapC Uniprot ID A0A6M7UJH1
Locus tag EB233_RS12515 Protein ID WP_064989603.1
Coordinates 2592981..2593370 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6M7URQ1
Locus tag EB233_RS12520 Protein ID WP_064989634.1
Coordinates 2593367..2593633 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB233_RS12485 2588820..2589425 - 606 WP_064989609.1 helix-turn-helix transcriptional regulator -
EB233_RS12490 2589492..2589917 + 426 WP_064989608.1 VOC family protein -
EB233_RS12495 2590024..2590245 + 222 WP_155765355.1 hypothetical protein -
EB233_RS12500 2590285..2591232 - 948 WP_064989606.1 trypsin-like peptidase domain-containing protein -
EB233_RS12505 2591458..2592330 + 873 WP_064989605.1 S1C family serine protease -
EB233_RS12510 2592339..2592974 + 636 WP_064989604.1 helix-turn-helix transcriptional regulator -
EB233_RS12515 2592981..2593370 - 390 WP_064989603.1 type II toxin-antitoxin system VapC family toxin Toxin
EB233_RS12520 2593367..2593633 - 267 WP_064989634.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EB233_RS12525 2593811..2594677 + 867 WP_064989602.1 NAD(P)-dependent oxidoreductase -
EB233_RS12530 2594720..2595424 - 705 WP_064989601.1 class I SAM-dependent methyltransferase -
EB233_RS12535 2595509..2596282 + 774 WP_064989633.1 AraC family transcriptional regulator -
EB233_RS12540 2596333..2596851 - 519 WP_032918048.1 TIGR00645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14375.69 Da        Isoelectric Point: 6.4660

>T113538 WP_064989603.1 NZ_CP033361:c2593370-2592981 [Mesorhizobium erdmanii]
MIIDSSVLVAIFRLEPGYERFVLALTQAKRKLLPAPTFLETTMVLAGGWQDEILDRLDRFLRTASIETIAFTADHAAVAR
QAFLRYGKGRHPAALNFGDCIAYATARLESMPLLFKGDDFRLTDIEAAV

Download         Length: 390 bp

>T113538 NZ_CP033361:c2593370-2592981 [Mesorhizobium erdmanii]
ATGATCATCGATTCGTCGGTCTTGGTCGCCATTTTCCGTCTCGAGCCGGGGTACGAACGTTTCGTGCTGGCGCTCACGCA
AGCCAAGAGGAAACTGTTGCCAGCGCCAACCTTTCTTGAAACCACAATGGTGCTCGCAGGCGGTTGGCAGGATGAAATTC
TGGACCGTCTCGACCGCTTCCTGCGCACCGCCTCAATCGAGACAATTGCCTTCACGGCGGACCATGCAGCCGTCGCCCGT
CAGGCCTTCCTGCGTTACGGCAAAGGCCGGCATCCGGCCGCGCTGAACTTCGGTGACTGTATCGCTTACGCCACGGCCCG
GCTCGAATCCATGCCGCTGCTGTTCAAGGGCGACGATTTCCGGCTGACCGATATCGAGGCGGCAGTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10128.54 Da        Isoelectric Point: 5.2709

>AT113538 WP_064989634.1 NZ_CP033361:c2593633-2593367 [Mesorhizobium erdmanii]
MALSIKNTEVEQLARELARRRRVSVTEAIRQSLEREVARERLVPREDASDLFQRLMAIAESAGRIPKRENAMTEDEILGY
DEFGIPTK

Download         Length: 267 bp

>AT113538 NZ_CP033361:c2593633-2593367 [Mesorhizobium erdmanii]
ATGGCTCTGTCGATCAAGAACACGGAAGTCGAACAACTCGCGCGGGAACTTGCCCGCCGCCGCCGCGTGTCCGTGACAGA
GGCTATCCGTCAGAGCCTTGAGCGCGAGGTTGCACGAGAGCGACTGGTGCCTCGCGAAGACGCTAGTGATCTGTTTCAGC
GGTTAATGGCGATTGCTGAGAGCGCCGGAAGAATCCCCAAACGCGAAAATGCGATGACCGAGGACGAAATCCTCGGTTAT
GACGAGTTCGGAATCCCGACGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M7UJH1

Antitoxin

Source ID Structure
AlphaFold DB A0A6M7URQ1

References