Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3307..3899 Replicon plasmid pEQAS2016S1-2
Accession NZ_CP033357
Organism Salmonella enterica subsp. enterica strain EQAS2016S1

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag EB781_RS00035 Protein ID WP_000520549.1
Coordinates 3307..3555 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag EB781_RS00040 Protein ID WP_000681613.1
Coordinates 3552..3899 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB781_RS00005 184..699 + 516 WP_001025395.1 J domain-containing protein -
EB781_RS00010 804..1346 + 543 WP_001083906.1 hypothetical protein -
EB781_RS00015 1343..1594 + 252 WP_001230707.1 hypothetical protein -
EB781_RS00020 1581..1808 + 228 WP_000801440.1 hypothetical protein -
EB781_RS00025 2262..2561 + 300 WP_000650309.1 hypothetical protein -
EB781_RS00030 2652..3002 + 351 WP_000854259.1 hypothetical protein -
EB781_RS00035 3307..3555 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
EB781_RS00040 3552..3899 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EB781_RS00045 4260..4763 + 504 WP_000781813.1 hypothetical protein -
EB781_RS00050 4767..5996 + 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
EB781_RS00055 6073..6366 + 294 WP_060598542.1 LuxR family transcriptional regulator -
EB781_RS00060 6363..6578 + 216 WP_000760375.1 EexN family lipoprotein -
EB781_RS00065 6934..7554 + 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
EB781_RS00070 7622..7894 + 273 WP_001328551.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33334 33334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 10656.47 Da        Isoelectric Point: 12.7138

>T113536 WP_000520549.1 NZ_CP033357:3307-3555 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Download         Length: 249 bp

>T113536 NZ_CP033357:3307-3555 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 14886.21 Da        Isoelectric Point: 12.8607

>AT113536 WP_000681613.1 NZ_CP033357:3552-3899 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 348 bp

>AT113536 NZ_CP033357:3552-3899 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References