113534

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 1985..2478 Replicon plasmid pCFSA664-3
Accession NZ_CP033355
Organism Salmonella enterica subsp. enterica strain CFSA664

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag EB780_RS03890 Protein ID WP_001230709.1
Coordinates 1985..2239 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag EB780_RS03895 Protein ID WP_000151456.1
Coordinates 2236..2478 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB780_RS03875 97..426 + 330 WP_001542022.1 hypothetical protein -
EB780_RS03880 827..1342 + 516 WP_001025393.1 J domain-containing protein -
EB780_RS03885 1446..1988 + 543 WP_001083904.1 hypothetical protein -
EB780_RS03890 1985..2239 + 255 WP_001230709.1 hypothetical protein Toxin
EB780_RS03895 2236..2478 + 243 WP_000151456.1 hypothetical protein Antitoxin
EB780_RS03905 3049..3336 + 288 WP_000673430.1 hypothetical protein -
EB780_RS03910 3346..3762 + 417 WP_053882499.1 phage tail protein -
EB780_RS03915 3759..4070 + 312 WP_001310436.1 hypothetical protein -
EB780_RS03920 4492..4674 - 183 WP_001401700.1 hypothetical protein -
EB780_RS03925 5232..5414 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
EB780_RS03930 5439..5876 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
EB780_RS03935 6007..6333 - 327 WP_129422592.1 hypothetical protein -
EB780_RS03940 6353..7060 - 708 WP_000108794.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..61841 61841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10912.81 Da        Isoelectric Point: 12.7242

>T113534 WP_001230709.1 NZ_CP033355:1985-2239 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKK

Download         Length: 255 bp

>T113534 NZ_CP033355:1985-2239 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 10400.12 Da        Isoelectric Point: 12.7030

>AT113534 WP_000151456.1 NZ_CP033355:2236-2478 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Download         Length: 243 bp

>AT113534 NZ_CP033355:2236-2478 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References