Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 97232..97875 Replicon plasmid pCFSA664-1
Accession NZ_CP033353
Organism Salmonella enterica subsp. enterica strain CFSA664

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag EB780_RS02715 Protein ID WP_001044768.1
Coordinates 97232..97648 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag EB780_RS02720 Protein ID WP_001261287.1
Coordinates 97645..97875 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB780_RS02700 93731..94321 - 591 WP_000194575.1 hypothetical protein -
EB780_RS02705 94321..94578 - 258 WP_000343085.1 hypothetical protein -
EB780_RS02710 94932..97070 + 2139 WP_000350638.1 AAA family ATPase -
EB780_RS02715 97232..97648 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
EB780_RS02720 97645..97875 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EB780_RS02730 98171..98461 + 291 WP_000111771.1 hypothetical protein -
EB780_RS02735 98451..99350 + 900 WP_000963206.1 nucleotide-binding protein -
EB780_RS02740 99400..101625 - 2226 WP_000698737.1 phage T7 exclusion protein -
EB780_RS02745 101627..102715 - 1089 WP_000952217.1 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-65 / fosA3 / blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / dfrA17 / aadA5 / oqxB / oqxA / armA / aph(3')-IIa / mph(A) / tet(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / floR - 1..255327 255327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T113532 WP_001044768.1 NZ_CP033353:c97648-97232 [Salmonella enterica subsp. enterica]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T113532 NZ_CP033353:c97648-97232 [Salmonella enterica subsp. enterica]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT113532 WP_001261287.1 NZ_CP033353:c97875-97645 [Salmonella enterica subsp. enterica]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT113532 NZ_CP033353:c97875-97645 [Salmonella enterica subsp. enterica]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References