Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3239..3831 Replicon plasmid pCFSA231
Accession NZ_CP033349
Organism Salmonella enterica subsp. enterica strain CFSA231

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag EB778_RS00275 Protein ID WP_000520549.1
Coordinates 3239..3487 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag EB778_RS00280 Protein ID WP_000681613.1
Coordinates 3484..3831 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB778_RS00240 116..631 + 516 WP_001025395.1 J domain-containing protein -
EB778_RS00245 736..1278 + 543 WP_001083906.1 hypothetical protein -
EB778_RS00250 1275..1526 + 252 WP_001230707.1 hypothetical protein -
EB778_RS00255 1513..1740 + 228 WP_000801440.1 hypothetical protein -
EB778_RS00265 2194..2493 + 300 WP_000650309.1 hypothetical protein -
EB778_RS00270 2584..2934 + 351 WP_000854259.1 hypothetical protein -
EB778_RS00275 3239..3487 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
EB778_RS00280 3484..3831 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EB778_RS00290 4192..4695 + 504 WP_000781813.1 hypothetical protein -
EB778_RS00295 4699..5928 + 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
EB778_RS00300 6005..6298 + 294 WP_060598542.1 LuxR family transcriptional regulator -
EB778_RS00305 6295..6510 + 216 WP_000760375.1 EexN family lipoprotein -
EB778_RS00310 6866..7486 + 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
EB778_RS00315 7554..7826 + 273 WP_001328551.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33309 33309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 10656.47 Da        Isoelectric Point: 12.7138

>T113529 WP_000520549.1 NZ_CP033349:3239-3487 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Download         Length: 249 bp

>T113529 NZ_CP033349:3239-3487 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 14886.21 Da        Isoelectric Point: 12.8607

>AT113529 WP_000681613.1 NZ_CP033349:3484-3831 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 348 bp

>AT113529 NZ_CP033349:3484-3831 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References