Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 112315..113938 Replicon plasmid pCFSA1096
Accession NZ_CP033347
Organism Salmonella enterica subsp. enterica strain CFSA1096

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag EB777_RS02145 Protein ID WP_000088046.1
Coordinates 112613..113938 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag EB777_RS02140 Protein ID WP_024136327.1
Coordinates 112315..112608 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB777_RS02105 107857..108138 - 282 WP_000077926.1 hypothetical protein -
EB777_RS02110 108188..108379 - 192 WP_000398480.1 hypothetical protein -
EB777_RS02115 108603..109775 + 1173 WP_000952349.1 IS21 family transposase -
EB777_RS02120 109775..110572 + 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
EB777_RS02125 110611..110946 - 336 WP_065311125.1 hypothetical protein -
EB777_RS02130 111319..111711 + 393 WP_000341066.1 hypothetical protein -
EB777_RS02140 112315..112608 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
EB777_RS02145 112613..113938 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
EB777_RS02150 113999..114205 + 207 WP_000134171.1 hypothetical protein -
EB777_RS02155 114307..114717 + 411 WP_000985911.1 hypothetical protein -
EB777_RS02160 114730..115545 + 816 WP_001572439.1 HNH endonuclease -
EB777_RS02165 115799..116224 + 426 WP_001043843.1 hypothetical protein -
EB777_RS02170 116773..117081 + 309 WP_001224687.1 hypothetical protein -
EB777_RS02175 117097..117954 + 858 WP_000784387.1 HNH endonuclease -
EB777_RS02180 118016..118219 + 204 WP_001194555.1 hypothetical protein -
EB777_RS02185 118561..118845 - 285 Protein_111 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..297348 297348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 56670.97 Da        Isoelectric Point: 13.4444

>T113527 WP_000088046.1 NZ_CP033347:112613-113938 [Salmonella enterica subsp. enterica]
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KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 1326 bp

>T113527 NZ_CP033347:112613-113938 [Salmonella enterica subsp. enterica]
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AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 12579.08 Da        Isoelectric Point: 12.7867

>AT113527 WP_024136327.1 NZ_CP033347:112315-112608 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Download         Length: 294 bp

>AT113527 NZ_CP033347:112315-112608 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References