Detailed information of TA system TA113525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/Xre(antitoxin)
• Location: 8798..9299
• Replicon: plasmid pCFSAN076214_1
• Accession: NZ_CP033341
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN076214

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: Q9F571
• Locus tag: EAE33_RS23410
• Protein ID: WP_000702246.1
• Coordinates: 8798..9058 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: -
• Locus tag: EAE33_RS23415
• Protein ID: WP_001132407.1
• Coordinates: 9048..9299 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAE33_RS23365	4390..4551	+	162	WP_001434039.1	type I toxin-antitoxin system Hok family toxin	-
EAE33_RS23370	4701..5297	+	597	WP_000125166.1	hypothetical protein	-
EAE33_RS24320	5315..5599	-	285	WP_001162371.1	hypothetical protein	-
EAE33_RS23380	5678..6343	-	666	WP_000532148.1	P-loop NTPase	-
EAE33_RS23390	6941..7270	+	330	WP_000855118.1	hypothetical protein	-
EAE33_RS23395	7851..8174	+	324	WP_000427402.1	hypothetical protein	-
EAE33_RS23400	8216..8425	+	210	WP_000866037.1	hypothetical protein	-
EAE33_RS23405	8523..8747	+	225	WP_000814384.1	hypothetical protein	-
EAE33_RS23410	8798..9058	+	261	WP_000702246.1	hypothetical protein	Toxin
EAE33_RS23415	9048..9299	+	252	WP_001132407.1	transcriptional regulator	Antitoxin
EAE33_RS23430	9849..10127	+	279	WP_000545937.1	hypothetical protein	-
EAE33_RS23435	10558..10824	+	267	WP_000681608.1	type II toxin-antitoxin system HicB family antitoxin	-
EAE33_RS23440	10931..11113	-	183	WP_001481829.1	hypothetical protein	-
EAE33_RS23445	11671..11853	+	183	WP_000833470.1	type II toxin-antitoxin system HicA family toxin	-
EAE33_RS23450	11878..12315	+	438	WP_000466318.1	type II toxin-antitoxin system HicB family antitoxin	-
EAE33_RS23455	12446..12901	-	456	WP_000206705.1	hypothetical protein	-
EAE33_RS23460	12921..13520	-	600	WP_000091423.1	hypothetical protein	-
EAE33_RS23465	13567..14268	-	702	WP_000280995.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59261	59261

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-108)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 11169.16 Da
• Isoelectric Point: 12.7344

>T113525 WP_000702246.1 NZ_CP033341:8798-9058 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKK

Nucleotide

• Length: 261 bp

>T113525 NZ_CP033341:8798-9058 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT113525 WP_001132407.1 NZ_CP033341:9048-9299 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT113525 NZ_CP033341:9048-9299 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A3E1XBA7