Detailed information of TA system TA113524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 77619..78144
• Replicon: plasmid pCFSAN076215
• Accession: NZ_CP033339
• Organism: Salmonella enterica subsp. enterica serovar Anatum strain CFSAN076215

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: EAE34_RS23825
• Protein ID: WP_079907959.1
• Coordinates: 77839..78144 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: I3VZQ6
• Locus tag: EAE34_RS23820
• Protein ID: WP_000813642.1
• Coordinates: 77619..77837 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAE34_RS23805	74328..75518	-	1191	WP_058344475.1	hypothetical protein	-
EAE34_RS23810	75952..76485	-	534	Protein_83	transposase family protein	-
EAE34_RS23815	76480..77020	+	541	Protein_84	IS110 family transposase	-
EAE34_RS23820	77619..77837	+	219	WP_000813642.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
EAE34_RS23825	77839..78144	+	306	WP_079907959.1	type II toxin-antitoxin system toxin CcdB	Toxin
EAE34_RS23830	78146..78436	+	291	WP_057394649.1	cytoplasmic protein	-
EAE34_RS23835	78433..79581	+	1149	WP_079961727.1	3'-5' exonuclease	-
EAE34_RS23840	79616..80398	+	783	WP_060634123.1	site-specific integrase	-
EAE34_RS23845	80632..81495	-	864	WP_060634124.1	RepB family plasmid replication initiator protein	-
EAE34_RS23850	82033..82674	+	642	WP_060634125.1	ParA family protein	-
EAE34_RS23855	82766..83104	+	339	WP_024262131.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..104123	104123

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (76-174)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T113524 WP_079907959.1 NZ_CP033339:77839-78144 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T113524 NZ_CP033339:77839-78144 [Salmonella enterica subsp. enterica serovar Anatum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT113524 WP_000813642.1 NZ_CP033339:77619-77837 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT113524 NZ_CP033339:77619-77837 [Salmonella enterica subsp. enterica serovar Anatum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A600YYQ0