Detailed information of TA system TA113522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1733458..1734070
• Replicon: chromosome
• Accession: NZ_CP033337
• Organism: Streptococcus pyogenes strain TSPY453

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: EB816_RS08955
• Protein ID: WP_002982731.1
• Coordinates: 1733735..1734070 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: EB816_RS08950
• Protein ID: WP_002988079.1
• Coordinates: 1733458..1733745 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB816_RS08925	1728666..1729649	-	984	WP_023611854.1	tagatose-bisphosphate aldolase	-
EB816_RS08930	1729653..1730582	-	930	WP_023611874.1	tagatose-6-phosphate kinase	-
EB816_RS08935	1730630..1731145	-	516	WP_014407849.1	galactose-6-phosphate isomerase subunit LacB	-
EB816_RS08940	1731180..1731608	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
EB816_RS08945	1732024..1732797	+	774	WP_002993783.1	DeoR/GlpR family DNA-binding transcription regulator	-
EB816_RS08950	1733458..1733745	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
EB816_RS08955	1733735..1734070	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EB816_RS10275	1734222..1734692	+	471	Protein_1657	tyrosine-type recombinase/integrase family protein	-
EB816_RS10280	1735054..1735155	+	102	WP_180372495.1	hypothetical protein	-
EB816_RS08975	1735335..1735727	-	393	WP_002982716.1	30S ribosomal protein S9	-
EB816_RS08980	1735748..1736194	-	447	WP_002982710.1	50S ribosomal protein L13	-
EB816_RS08985	1736412..1736618	-	207	WP_023611859.1	helix-turn-helix transcriptional regulator	-
EB816_RS08990	1736615..1737313	-	699	WP_023611871.1	hypothetical protein	-
EB816_RS08995	1737449..1738309	-	861	WP_023611214.1	DegV family protein	-
EB816_RS09000	1738406..1738924	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T113522 WP_002982731.1 NZ_CP033337:1733735-1734070 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T113522 NZ_CP033337:1733735-1734070 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT113522 WP_002988079.1 NZ_CP033337:1733458-1733745 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT113522 NZ_CP033337:1733458-1733745 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAATAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A4U7GX94