Detailed information of TA system TA113521

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1562165..1562777
• Replicon: chromosome
• Accession: NZ_CP033336
• Organism: Streptococcus pyogenes strain TSPY165

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: EB817_RS08020
• Protein ID: WP_002982731.1
• Coordinates: 1562442..1562777 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: EB817_RS08015
• Protein ID: WP_002988079.1
• Coordinates: 1562165..1562452 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB817_RS07990	1557344..1558327	-	984	WP_129304913.1	tagatose-bisphosphate aldolase	-
EB817_RS07995	1558331..1559260	-	930	WP_053308612.1	tagatose-6-phosphate kinase	-
EB817_RS08000	1559308..1559823	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
EB817_RS08005	1559858..1560286	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
EB817_RS08010	1560731..1561504	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
EB817_RS08015	1562165..1562452	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
EB817_RS08020	1562442..1562777	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EB817_RS09390	1562929..1563399	+	471	Protein_1460	integrase	-
EB817_RS08035	1563513..1563863	+	351	WP_111679863.1	tyrosine-type recombinase/integrase	-
EB817_RS08040	1564031..1564423	-	393	WP_002982716.1	30S ribosomal protein S9	-
EB817_RS08045	1564444..1564890	-	447	WP_002982710.1	50S ribosomal protein L13	-
EB817_RS08050	1565108..1565314	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
EB817_RS08055	1565311..1566009	-	699	WP_164976445.1	hypothetical protein	-
EB817_RS08060	1566145..1567005	-	861	WP_030127324.1	DegV family protein	-
EB817_RS08065	1567102..1567620	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T113521 WP_002982731.1 NZ_CP033336:1562442-1562777 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T113521 NZ_CP033336:1562442-1562777 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT113521 WP_002988079.1 NZ_CP033336:1562165-1562452 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT113521 NZ_CP033336:1562165-1562452 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A4U7GX94