Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 11663..12216 Replicon plasmid unnamed
Accession NZ_CP033327
Organism Xanthomonas cucurbitae strain ATCC 23378

Toxin (Protein)


Gene name relE Uniprot ID A0A1L5QZG5
Locus tag EBN15_RS20030 Protein ID WP_054471487.1
Coordinates 11923..12216 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6M2VV98
Locus tag EBN15_RS20025 Protein ID WP_005933935.1
Coordinates 11663..11935 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EBN15_RS19995 6906..7214 - 309 WP_159408047.1 hypothetical protein -
EBN15_RS20000 7432..8907 - 1476 WP_159408048.1 replication protein -
EBN15_RS20005 9124..9438 - 315 WP_159408049.1 partition protein -
EBN15_RS20010 9522..9851 - 330 WP_011997475.1 hypothetical protein -
EBN15_RS20015 9844..10476 - 633 WP_007966093.1 ParA family protein -
EBN15_RS20020 10555..11466 - 912 WP_159408050.1 recombinase family protein -
EBN15_RS20025 11663..11935 + 273 WP_005933935.1 CopG family ribbon-helix-helix protein Antitoxin
EBN15_RS20030 11923..12216 + 294 WP_054471487.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EBN15_RS20035 12216..12581 + 366 WP_159408051.1 XRE family transcriptional regulator -
EBN15_RS20040 12578..12925 + 348 WP_159408052.1 transcriptional regulator -
EBN15_RS20045 13144..13377 - 234 WP_159408053.1 type I toxin-antitoxin system ptaRNA1 family toxin -
EBN15_RS20050 13438..13701 - 264 WP_159408054.1 hypothetical protein -
EBN15_RS20155 13704..13958 - 255 WP_167527030.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..14239 14239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10811.34 Da        Isoelectric Point: 5.1583

>T113515 WP_054471487.1 NZ_CP033327:11923-12216 [Xanthomonas cucurbitae]
VPQVIVTEGAAEGLERCRRFLAVKAPDAARRAGQAIERQFLLLETAPDIGRPFPEMPELRELVIAFGDSGYVALYRHEPA
DDAVYVLAFRHQKEAGY

Download         Length: 294 bp

>T113515 NZ_CP033327:11923-12216 [Xanthomonas cucurbitae]
GTGCCACAAGTAATCGTCACCGAAGGCGCGGCGGAAGGCTTGGAACGATGCCGGCGGTTCCTGGCCGTCAAGGCACCGGA
CGCCGCCAGGCGTGCCGGCCAGGCCATCGAGCGGCAATTCCTGCTGCTGGAGACGGCCCCCGACATTGGCCGGCCGTTCC
CTGAAATGCCCGAGCTGCGCGAGCTGGTGATTGCCTTCGGGGATTCCGGCTATGTGGCCCTGTACCGCCACGAACCGGCC
GACGATGCGGTGTATGTTCTGGCCTTCCGGCACCAGAAAGAGGCAGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10545.84 Da        Isoelectric Point: 8.1081

>AT113515 WP_005933935.1 NZ_CP033327:11663-11935 [Xanthomonas cucurbitae]
MATSLKIDDTLKGRVHHLASQRRRSPHWIMLEAIQQYVEREEARESFKQEALASWAAYKETGRHLTGQEVRTWLNTWGTS
DERAVPECHK

Download         Length: 273 bp

>AT113515 NZ_CP033327:11663-11935 [Xanthomonas cucurbitae]
ATGGCAACGTCTCTCAAGATCGACGACACGCTGAAAGGTCGAGTCCACCACCTCGCCAGCCAGCGCCGCCGCTCGCCCCA
CTGGATCATGCTCGAAGCGATCCAGCAGTACGTCGAGCGCGAAGAAGCCCGCGAGAGCTTCAAGCAGGAAGCCTTGGCAT
CCTGGGCGGCCTACAAGGAAACCGGCCGTCACCTGACCGGCCAGGAAGTTCGCACCTGGTTGAACACCTGGGGCACCAGT
GACGAAAGGGCGGTGCCTGAGTGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5QZG5

Antitoxin

Source ID Structure
AlphaFold DB A0A6M2VV98

References