Detailed information of TA system TA113510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 9061..9653
• Replicon: plasmid pCFSA244-2
• Accession: NZ_CP033254
• Organism: Salmonella enterica subsp. enterica strain CFSA244

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1I9ZJC5
• Locus tag: EB533_RS02060
• Protein ID: WP_000513532.1
• Coordinates: 9061..9309 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1I9ZJ49
• Locus tag: EB533_RS02065
• Protein ID: WP_000681609.1
• Coordinates: 9306..9653 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB533_RS02015	4073..4738	-	666	WP_000532149.1	P-loop NTPase	-
EB533_RS02025	5327..5656	+	330	WP_001542022.1	hypothetical protein	-
EB533_RS02030	6057..6572	+	516	WP_001025393.1	J domain-containing protein	-
EB533_RS02035	6676..7218	+	543	WP_001083904.1	hypothetical protein	-
EB533_RS02040	7215..7469	+	255	WP_001230709.1	hypothetical protein	-
EB533_RS02045	7466..7708	+	243	WP_000151456.1	hypothetical protein	-
EB533_RS02055	8279..8572	+	294	WP_000673428.1	hypothetical protein	-
EB533_RS02060	9061..9309	+	249	WP_000513532.1	type II toxin-antitoxin system HicA family toxin	Toxin
EB533_RS02065	9306..9653	+	348	WP_000681609.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EB533_RS02070	9741..9923	-	183	WP_001428470.1	hypothetical protein	-
EB533_RS02075	10425..10724	+	300	WP_034169410.1	type II toxin-antitoxin system HicB family antitoxin	-
EB533_RS02080	10984..11310	-	327	WP_000206697.1	hypothetical protein	-
EB533_RS02085	11312..11671	-	360	WP_024147837.1	hypothetical protein	-
EB533_RS02090	11772..12479	-	708	WP_000108794.1	hypothetical protein	-
EB533_RS02095	12481..13233	-	753	WP_000797966.1	conjugal transfer protein TraL	-
EB533_RS02100	13251..13652	-	402	WP_021575837.1	hypothetical protein	-
EB533_RS02105	14020..14361	+	342	WP_000730722.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..60381	60381

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-80)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 10656.47 Da
• Isoelectric Point: 12.7138

>T113510 WP_000513532.1 NZ_CP033254:9061-9309 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Nucleotide

• Length: 249 bp

>T113510 NZ_CP033254:9061-9309 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 14886.21 Da
• Isoelectric Point: 12.8607

>AT113510 WP_000681609.1 NZ_CP033254:9306-9653 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 348 bp

>AT113510 NZ_CP033254:9306-9653 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A1I9ZJC5

Antitoxin

• AlphaFold DB: A0A1I9ZJ49