Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 7215..7708 Replicon plasmid pCFSA244-2
Accession NZ_CP033254
Organism Salmonella enterica subsp. enterica strain CFSA244

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag EB533_RS02040 Protein ID WP_001230709.1
Coordinates 7215..7469 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag EB533_RS02045 Protein ID WP_000151456.1
Coordinates 7466..7708 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB533_RS02000 2790..2951 + 162 WP_001366886.1 type I toxin-antitoxin system Hok family toxin -
EB533_RS02005 3101..3697 + 597 WP_000125165.1 hypothetical protein -
EB533_RS02010 3715..3885 - 171 WP_000186151.1 hypothetical protein -
EB533_RS02015 4073..4738 - 666 WP_000532149.1 P-loop NTPase -
EB533_RS02025 5327..5656 + 330 WP_001542022.1 hypothetical protein -
EB533_RS02030 6057..6572 + 516 WP_001025393.1 J domain-containing protein -
EB533_RS02035 6676..7218 + 543 WP_001083904.1 hypothetical protein -
EB533_RS02040 7215..7469 + 255 WP_001230709.1 hypothetical protein Toxin
EB533_RS02045 7466..7708 + 243 WP_000151456.1 hypothetical protein Antitoxin
EB533_RS02055 8279..8572 + 294 WP_000673428.1 hypothetical protein -
EB533_RS02060 9061..9309 + 249 WP_000513532.1 type II toxin-antitoxin system HicA family toxin -
EB533_RS02065 9306..9653 + 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin -
EB533_RS02070 9741..9923 - 183 WP_001428470.1 hypothetical protein -
EB533_RS02075 10425..10724 + 300 WP_034169410.1 type II toxin-antitoxin system HicB family antitoxin -
EB533_RS02080 10984..11310 - 327 WP_000206697.1 hypothetical protein -
EB533_RS02085 11312..11671 - 360 WP_024147837.1 hypothetical protein -
EB533_RS02090 11772..12479 - 708 WP_000108794.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..60381 60381


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(6-43)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10912.81 Da        Isoelectric Point: 12.7242

>T113509 WP_001230709.1 NZ_CP033254:7215-7469 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKK

Download         Length: 255 bp

>T113509 NZ_CP033254:7215-7469 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 10400.12 Da        Isoelectric Point: 12.7030

>AT113509 WP_000151456.1 NZ_CP033254:7466-7708 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Download         Length: 243 bp

>AT113509 NZ_CP033254:7466-7708 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References