Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1197189..1197868 Replicon chromosome
Accession NZ_CP033243
Organism Acinetobacter baumannii strain 7835

Toxin (Protein)


Gene name hicA Uniprot ID A0A2S4SYJ5
Locus tag Aba7835_RS05685 Protein ID WP_002108505.1
Coordinates 1197189..1197371 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag Aba7835_RS05690 Protein ID WP_000966688.1
Coordinates 1197464..1197868 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aba7835_RS05650 1192426..1192824 + 399 WP_001251837.1 hypothetical protein -
Aba7835_RS05655 1192826..1193044 + 219 WP_001277696.1 hypothetical protein -
Aba7835_RS05660 1193153..1193674 + 522 WP_000749906.1 SH3 domain-containing protein -
Aba7835_RS05665 1193771..1194124 + 354 WP_000064612.1 hypothetical protein -
Aba7835_RS05670 1194124..1195308 + 1185 WP_118898345.1 phage tail protein -
Aba7835_RS05675 1195361..1196278 + 918 WP_000094250.1 hypothetical protein -
Aba7835_RS05680 1196348..1196863 + 516 WP_117345762.1 hypothetical protein -
Aba7835_RS05685 1197189..1197371 + 183 WP_002108505.1 type II toxin-antitoxin system HicA family toxin Toxin
Aba7835_RS05690 1197464..1197868 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Aba7835_RS05695 1197967..1198143 + 177 WP_075149899.1 hypothetical protein -
Aba7835_RS05700 1198152..1198475 + 324 WP_000523928.1 DUF4236 domain-containing protein -
Aba7835_RS05705 1198508..1198891 + 384 WP_000725050.1 hypothetical protein -
Aba7835_RS05710 1198953..1199699 + 747 WP_000599536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1164602..1213731 49129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6685.80 Da        Isoelectric Point: 10.5523

>T113477 WP_002108505.1 NZ_CP033243:1197189-1197371 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTISHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T113477 NZ_CP033243:1197189-1197371 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAAGGGTTAGTTACAATCTCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT113477 WP_000966688.1 NZ_CP033243:1197464-1197868 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT113477 NZ_CP033243:1197464-1197868 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4SYJ5

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References