Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2441067..2442046 Replicon chromosome
Accession NZ_CP033241
Organism Saccharolobus solfataricus strain SUL120

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SULZ_RS13415 Protein ID WP_009988462.1
Coordinates 2441067..2441681 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SULZ_RS13420 Protein ID WP_009988464.1
Coordinates 2441699..2442046 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULZ_RS13385 (SULZ_13400) 2437083..2437682 - 600 WP_009991466.1 DUF2249 domain-containing protein -
SULZ_RS13390 (SULZ_13405) 2438409..2438651 + 243 WP_009988456.1 hypothetical protein -
SULZ_RS13395 (SULZ_13410) 2438632..2438976 - 345 WP_009988458.1 hypothetical protein -
SULZ_RS13400 (SULZ_13415) 2438980..2439744 - 765 WP_009988459.1 plastocyanin/azurin family copper-binding protein -
SULZ_RS13405 (SULZ_13420) 2439850..2440380 - 531 WP_009988460.1 hemerythrin domain-containing protein -
SULZ_RS13410 (SULZ_13425) 2440502..2440777 + 276 WP_009988461.1 hypothetical protein -
SULZ_RS13415 (SULZ_13430) 2441067..2441681 - 615 WP_009988462.1 helix-turn-helix domain-containing protein Toxin
SULZ_RS13420 (SULZ_13435) 2441699..2442046 - 348 WP_009988464.1 DUF488 domain-containing protein Antitoxin
SULZ_RS13425 (SULZ_13440) 2442116..2442346 - 231 WP_009988466.1 C2H2-type zinc finger protein -
SULZ_RS13430 (SULZ_13445) 2442439..2442828 + 390 WP_009988467.1 metal-sulfur cluster assembly factor -
SULZ_RS13435 (SULZ_13450) 2442821..2443252 - 432 WP_009988468.1 universal stress protein -
SULZ_RS13440 (SULZ_13455) 2443678..2444610 - 933 WP_009988516.1 dipeptidase -
SULZ_RS13445 (SULZ_13460) 2444555..2445751 - 1197 WP_009988517.1 MFS transporter -
SULZ_RS13450 (SULZ_13465) 2445788..2446630 - 843 WP_009988518.1 KaiC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T113473 WP_009988462.1 NZ_CP033241:c2441681-2441067 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T113473 NZ_CP033241:c2441681-2441067 [Saccharolobus solfataricus]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT113473 WP_009988464.1 NZ_CP033241:c2442046-2441699 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT113473 NZ_CP033241:c2442046-2441699 [Saccharolobus solfataricus]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3MDP8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3GU05

References