Detailed information of TA system TA113472

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 2387783..2388430
• Replicon: chromosome
• Accession: NZ_CP033241
• Organism: Saccharolobus solfataricus strain SUL120

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SULZ_RS13080
• Protein ID: WP_009990357.1
• Coordinates: 2387783..2388055 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0E3K976
• Locus tag: SULZ_RS13085
• Protein ID: WP_009990356.1
• Coordinates: 2388170..2388430 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULZ_RS13060 (SULZ_13070)	2383098..2384149	-	1052	Protein_2537	ISH3-like element ISC1359 family transposase	-
SULZ_RS13065 (SULZ_13075)	2384253..2385002	+	750	Protein_2538	GDP-mannose 4,6-dehydratase	-
SULZ_RS13070 (SULZ_13090)	2386313..2387260	-	948	WP_009990359.1	ATP/GTP-binding protein	-
SULZ_RS13080 (SULZ_13100)	2387783..2388055	-	273	WP_009990357.1	PIN domain-containing protein	Toxin
SULZ_RS13085 (SULZ_13105)	2388170..2388430	-	261	WP_009990356.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SULZ_RS13090 (SULZ_13110)	2389116..2389277	+	162	WP_009990355.1	hypothetical protein	-
SULZ_RS13095 (SULZ_13115)	2389379..2389837	+	459	WP_009990354.1	hypothetical protein	-
SULZ_RS13100 (SULZ_13120)	2390586..2391092	-	507	WP_014511696.1	thiosulfate:quinone oxidoreductase small subunit	-
SULZ_RS13105 (SULZ_13125)	2391098..2391640	-	543	WP_009990352.1	thiosulfate:quinone oxidoreductase large subunit	-
SULZ_RS13110 (SULZ_13130)	2391948..2392823	-	876	Protein_2546	transposase	-
SULZ_RS13115 (SULZ_13135)	2393184..2393417	+	234	WP_009993269.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (20-82)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10475.34 Da
• Isoelectric Point: 9.7534

>T113472 WP_009990357.1 NZ_CP033241:c2388055-2387783 [Saccharolobus solfataricus]
MRLFTLSKKKYNVKFEDTIDFLDKIILPYTIILPINSHDYEKAKGIMISKTLKPSDAFHVAVMINNSIKKIVSEDSDFDK
INGIERIWVK

Nucleotide

• Length: 273 bp

>T113472 NZ_CP033241:c2388055-2387783 [Saccharolobus solfataricus]
ATGAGGTTATTTACATTATCAAAAAAGAAGTATAATGTAAAATTTGAGGATACAATTGATTTCTTAGATAAGATAATACT
TCCTTATACAATTATACTGCCAATCAACTCTCATGATTATGAAAAAGCAAAGGGGATAATGATAAGTAAGACTTTAAAAC
CGTCTGATGCTTTCCACGTAGCTGTAATGATAAATAATTCAATAAAAAAGATAGTAAGTGAGGATTCAGATTTCGATAAA
ATTAATGGAATAGAAAGGATTTGGGTAAAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9842.51 Da
• Isoelectric Point: 5.2456

>AT113472 WP_009990356.1 NZ_CP033241:c2388430-2388170 [Saccharolobus solfataricus]
MTLKIEVGKKGYIIIPKTVRDLLEIKEGDILILRVEDGKIVLEPERKVSFDDLKKKMEEHSAKISYANKAKLGDLINVSL
EEEFDN

Nucleotide

• Length: 261 bp

>AT113472 NZ_CP033241:c2388430-2388170 [Saccharolobus solfataricus]
TTGACCCTAAAGATTGAAGTTGGAAAGAAAGGATATATAATAATCCCTAAGACTGTTAGGGATCTTCTTGAAATAAAGGA
GGGAGATATATTAATCCTAAGAGTCGAAGATGGTAAAATTGTTCTTGAGCCTGAAAGAAAGGTAAGTTTTGATGACTTAA
AAAAGAAGATGGAGGAACATAGTGCTAAAATCTCATATGCAAATAAGGCTAAACTTGGAGATTTAATTAACGTTAGTTTA
GAGGAGGAATTCGATAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E3K976