Detailed information of TA system TA113471

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2174630..2175317
• Replicon: chromosome
• Accession: NZ_CP033241
• Organism: Saccharolobus solfataricus strain SUL120

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SULZ_RS11985
• Protein ID: WP_231918326.1
• Coordinates: 2174982..2175317 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SULZ_RS11980
• Protein ID: WP_009991659.1
• Coordinates: 2174630..2174932 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULZ_RS11960 (SULZ_11950)	2170553..2171096	-	544	Protein_2317	IS607 family transposase	-
SULZ_RS11965 (SULZ_11955)	2171424..2172091	+	668	Protein_2318	ISNCY family transposase	-
SULZ_RS11970 (SULZ_11960)	2172500..2173072	-	573	WP_010923431.1	metallophosphoesterase	-
SULZ_RS11975 (SULZ_11965)	2173088..2174101	-	1014	WP_010923639.1	IS630-like element ISC1078 family transposase	-
SULZ_RS11980 (SULZ_11970)	2174630..2174932	+	303	WP_009991659.1	hypothetical protein	Antitoxin
SULZ_RS11985 (SULZ_11975)	2174982..2175317	+	336	WP_231918326.1	type II toxin-antitoxin system VapC family toxin	Toxin
SULZ_RS11990 (SULZ_11980)	2175525..2176640	+	1116	WP_009991657.1	hypothetical protein	-
SULZ_RS11995 (SULZ_11985)	2176784..2177119	-	336	Protein_2324	transposase	-
SULZ_RS12000 (SULZ_11990)	2177301..2177446	-	146	Protein_2325	IS630 family transposase	-
SULZ_RS15185	2177391..2177582	+	192	WP_048056702.1	hypothetical protein	-
SULZ_RS12010 (SULZ_12000)	2177842..2178339	-	498	WP_014511660.1	hypothetical protein	-
SULZ_RS12015 (SULZ_12005)	2178481..2179454	-	974	Protein_2328	IS5 family transposase	-
SULZ_RS12020 (SULZ_12010)	2179579..2179917	+	339	WP_010923427.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2132047..2354126	222079
	-	inside	IScluster/Tn	-	-	2169319..2183096	13777

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-104)

Antitoxin

• Putative antitoxin VapB3-like (28-100)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12427.61 Da
• Isoelectric Point: 5.2389

>T113471 WP_231918326.1 NZ_CP033241:2174982-2175317 [Saccharolobus solfataricus]
IREILKDAETLDFALVEVSNVVWKKAVLTGELTGKDVIKAITIVKEYLPQLLTVNKSIDLIERAIEISVNEKITVYDSLY
IALAECKGSKLVTGDKKQYDVAKKYVISELI

Nucleotide

• Length: 336 bp

>T113471 NZ_CP033241:2174982-2175317 [Saccharolobus solfataricus]
ATTAGAGAGATTTTGAAAGACGCTGAGACATTAGACTTCGCATTAGTGGAAGTATCTAACGTAGTATGGAAGAAAGCTGT
ATTAACTGGGGAATTAACTGGGAAAGATGTAATTAAGGCAATTACTATTGTTAAAGAGTATTTACCACAACTGCTTACAG
TTAACAAAAGCATTGACTTAATTGAAAGAGCTATTGAGATTTCCGTTAACGAGAAAATCACAGTATATGATTCACTTTAT
ATTGCACTGGCTGAATGTAAGGGGAGTAAATTGGTAACGGGGGATAAGAAACAATACGACGTAGCTAAAAAGTACGTCAT
CTCTGAGCTCATATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12195.09 Da
• Isoelectric Point: 4.8275

>AT113471 WP_009991659.1 NZ_CP033241:2174630-2174932 [Saccharolobus solfataricus]
MVIKNATILIYVPEIETFIFPVYVYYNMKTVYSLRLDKELREEMEKYNVKWNEEIESFIRKRIEELKKEEILKKINEILQ
TMPETKSNSADLVREDRDNN

Nucleotide

• Length: 303 bp

>AT113471 NZ_CP033241:2174630-2174932 [Saccharolobus solfataricus]
ATGGTAATAAAGAATGCTACAATTTTAATCTATGTACCAGAGATAGAAACGTTTATATTTCCCGTATACGTGTATTATAA
TATGAAAACCGTATACAGTTTAAGGTTAGATAAGGAATTACGTGAGGAGATGGAGAAATATAACGTCAAGTGGAATGAGG
AGATAGAGAGCTTTATAAGAAAGAGAATTGAGGAATTGAAGAAAGAGGAGATCTTAAAGAAGATTAATGAAATCCTCCAA
ACAATGCCAGAAACTAAGTCAAATAGTGCAGATTTGGTGAGGGAAGATAGGGATAATAATTGA