Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2019409..2020015 Replicon chromosome
Accession NZ_CP033241
Organism Saccharolobus solfataricus strain SUL120

Toxin (Protein)


Gene name vapC Uniprot ID Q97YS3
Locus tag SULZ_RS11335 Protein ID WP_009993017.1
Coordinates 2019623..2020015 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3G8ES43
Locus tag SULZ_RS11330 Protein ID WP_009993015.1
Coordinates 2019409..2019633 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULZ_RS11305 (SULZ_11275) 2014557..2015687 + 1131 WP_009992604.1 aromatic/alkene monooxygenase hydroxylase subunit beta -
SULZ_RS11310 (SULZ_11280) 2015684..2016145 + 462 WP_010923265.1 metal-sulfur cluster assembly factor -
SULZ_RS11315 (SULZ_11285) 2016188..2017103 - 916 Protein_2190 IS110 family transposase -
SULZ_RS11320 (SULZ_11290) 2017148..2018131 + 984 WP_010923242.1 IS630-like element ISC1048 family transposase -
SULZ_RS11325 (SULZ_11295) 2018130..2019099 + 970 Protein_2192 IS110 family transposase -
SULZ_RS11330 (SULZ_11300) 2019409..2019633 + 225 WP_009993015.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SULZ_RS11335 (SULZ_11305) 2019623..2020015 + 393 WP_009993017.1 type II toxin-antitoxin system VapC family toxin Toxin
SULZ_RS11340 (SULZ_11310) 2020458..2020936 - 479 Protein_2195 ISNCY family transposase -
SULZ_RS11345 (SULZ_11315) 2021054..2022106 + 1053 WP_010923271.1 ISH3 family transposase -
SULZ_RS11350 (SULZ_11320) 2022294..2022881 - 588 Protein_2197 ISNCY family transposase -
SULZ_RS11355 (SULZ_11325) 2023315..2023656 - 342 WP_009990179.1 nucleotidyltransferase domain-containing protein -
SULZ_RS11360 (SULZ_11330) 2023647..2023994 - 348 WP_014511635.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2011132..2022881 11749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15117.81 Da        Isoelectric Point: 9.3474

>T113470 WP_009993017.1 NZ_CP033241:2019623-2020015 [Saccharolobus solfataricus]
MKDKEFLLDASALYSLLDYVDKVDVKKIHVLTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVIEDSPLEGV
MRIAIERGLTYYNASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T113470 NZ_CP033241:2019623-2020015 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCTTGCTCGATGCCTCAGCTTTGTATTCACTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATGTACTTACCCTAACTTTTTATGAGGTAGGTAATGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCTATAAATTAATGCGAAAATTTAACGTAATAGAGGATTCGCCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATAACGCATCTTATGCGTATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAACGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8840.20 Da        Isoelectric Point: 5.0190

>AT113470 WP_009993015.1 NZ_CP033241:2019409-2019633 [Saccharolobus solfataricus]
MSDVISVRVKKELKKKAEELGINVREVVEKALEEAIREKEKEELKDMTMKIKELMRDVSEYDWVSTVRESRDER

Download         Length: 225 bp

>AT113470 NZ_CP033241:2019409-2019633 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGAGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTAGGAATTAACGTTAGGGAAGT
TGTAGAAAAAGCTTTAGAGGAAGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGACTATGAAAATTAAGGAAC
TAATGAGGGACGTAAGTGAATATGATTGGGTAAGTACTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3GVD1

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8ES43

References