Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 828417..829023 Replicon chromosome
Accession NZ_CP033241
Organism Saccharolobus solfataricus strain SUL120

Toxin (Protein)


Gene name vapC Uniprot ID Q97UE3
Locus tag SULZ_RS04400 Protein ID WP_009989090.1
Coordinates 828417..828821 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9UBQ9
Locus tag SULZ_RS04405 Protein ID WP_009989091.1
Coordinates 828802..829023 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULZ_RS04365 (SULZ_04375) 823919..824680 - 762 WP_009990867.1 ZIP family metal transporter -
SULZ_RS04370 (SULZ_04380) 824828..825010 - 183 WP_009990866.1 hypothetical protein -
SULZ_RS04380 (SULZ_04390) 825846..826625 + 780 WP_014511459.1 DMT family transporter -
SULZ_RS04385 (SULZ_04395) 827063..827787 + 725 Protein_871 transposase -
SULZ_RS04390 (SULZ_04400) 827785..827892 - 108 Protein_872 IS110 family transposase -
SULZ_RS04395 (SULZ_04405) 827934..828221 + 288 WP_272898411.1 transposase -
SULZ_RS04400 (SULZ_04410) 828417..828821 - 405 WP_009989090.1 PIN domain-containing protein Toxin
SULZ_RS04405 (SULZ_04415) 828802..829023 - 222 WP_009989091.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SULZ_RS04410 (SULZ_04420) 829552..829752 + 201 WP_009989095.1 hypothetical protein -
SULZ_RS04415 (SULZ_04425) 829806..830036 + 231 WP_009989096.1 EamA family transporter -
SULZ_RS04420 (SULZ_04430) 830147..831418 + 1272 WP_009989097.1 MFS transporter -
SULZ_RS04425 (SULZ_04435) 831537..832202 + 666 WP_009989098.1 helix-turn-helix domain-containing protein -
SULZ_RS04430 (SULZ_04440) 832199..832585 - 387 WP_009989099.1 hypothetical protein -
SULZ_RS04435 (SULZ_04445) 832582..833199 - 618 WP_009989100.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15426.98 Da        Isoelectric Point: 5.0272

>T113469 WP_009989090.1 NZ_CP033241:c828821-828417 [Saccharolobus solfataricus]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLNKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS

Download         Length: 405 bp

>T113469 NZ_CP033241:c828821-828417 [Saccharolobus solfataricus]
GTGGAGAAGGCAATAGTTGACACTAACGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCGGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTGGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATATTAGAAGTGAGAAAGCTGAGGTTGTCTGCGATTGTACAGATAACGTC
ACTGACGCTATAGGAGTGCTGAATAAGGAAAAGCTTCCCTTGGTCAGCTACAAAGATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGAAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTGCTACAGT
CGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8267.50 Da        Isoelectric Point: 9.6908

>AT113469 WP_009989091.1 NZ_CP033241:c829023-828802 [Saccharolobus solfataricus]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS

Download         Length: 222 bp

>AT113469 NZ_CP033241:c829023-828802 [Saccharolobus solfataricus]
ATGGAGAGGGTAAAGGTTACGAGAAATTACCAGATAACTATTCCAGCCTCGGCTAGGAGTAAGATTAATATAAAAGAAGG
AGATATACTTGAGGTTTACTTGAACGGTGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAG
GCAGTAAACTCTCACTGGGAGATATTGAGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3K068

Antitoxin

Source ID Structure
AlphaFold DB M9UBQ9

References