Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2528902..2529508 | Replicon | chromosome |
| Accession | NZ_CP033240 | ||
| Organism | Saccharolobus solfataricus strain SARC-O | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q97WY9 |
| Locus tag | SULO_RS14155 | Protein ID | WP_009991922.1 |
| Coordinates | 2529116..2529508 (+) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | C3NC15 |
| Locus tag | SULO_RS14150 | Protein ID | WP_009991920.1 |
| Coordinates | 2528902..2529126 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SULO_RS14115 (SULO_14155) | 2524146..2525087 | - | 942 | WP_124405879.1 | IS110 family transposase | - |
| SULO_RS14120 (SULO_14160) | 2525246..2525530 | + | 285 | Protein_2739 | IS607-like element ISC1913 family transposase | - |
| SULO_RS14125 (SULO_14165) | 2525514..2526734 | + | 1221 | WP_014511730.1 | IS200/IS605 family accessory protein TnpB-related protein | - |
| SULO_RS14130 (SULO_14170) | 2526882..2527268 | - | 387 | WP_009991912.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULO_RS14135 (SULO_14175) | 2527255..2527530 | - | 276 | WP_009991915.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SULO_RS14140 (SULO_14180) | 2527901..2528137 | + | 237 | WP_009991916.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SULO_RS14145 (SULO_14185) | 2528115..2528513 | + | 399 | WP_009991918.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULO_RS14150 (SULO_14190) | 2528902..2529126 | + | 225 | WP_009991920.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| SULO_RS14155 (SULO_14195) | 2529116..2529508 | + | 393 | WP_009991922.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SULO_RS14160 (SULO_14200) | 2529682..2530632 | + | 951 | WP_010923701.1 | IS110 family transposase | - |
| SULO_RS14165 (SULO_14205) | 2530706..2531755 | - | 1050 | Protein_2748 | AMP-binding protein | - |
| SULO_RS14170 (SULO_14210) | 2531856..2532971 | + | 1116 | WP_009988843.1 | acyl-CoA dehydrogenase family protein | - |
| SULO_RS14175 (SULO_14215) | 2533034..2534179 | + | 1146 | WP_009988841.1 | thiolase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 2510792..2530632 | 19840 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 15105.86 Da Isoelectric Point: 8.2957
>T113468 WP_009991922.1 NZ_CP033240:2529116-2529508 [Saccharolobus solfataricus]
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
Download Length: 393 bp
>T113468 NZ_CP033240:2529116-2529508 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8881.24 Da Isoelectric Point: 5.0355
>AT113468 WP_009991920.1 NZ_CP033240:2528902-2529126 [Saccharolobus solfataricus]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
Download Length: 225 bp
>AT113468 NZ_CP033240:2528902-2529126 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3K6Y2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3MHL6 |