Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2399612..2400591 Replicon chromosome
Accession NZ_CP033240
Organism Saccharolobus solfataricus strain SARC-O

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SULO_RS13375 Protein ID WP_009988462.1
Coordinates 2399612..2400226 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SULO_RS13380 Protein ID WP_009988464.1
Coordinates 2400244..2400591 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULO_RS13345 (SULO_13380) 2395628..2396227 - 600 WP_009991466.1 DUF2249 domain-containing protein -
SULO_RS13350 (SULO_13385) 2396954..2397196 + 243 WP_009988456.1 hypothetical protein -
SULO_RS13355 (SULO_13390) 2397177..2397521 - 345 WP_009988458.1 hypothetical protein -
SULO_RS13360 (SULO_13395) 2397525..2398289 - 765 WP_009988459.1 plastocyanin/azurin family copper-binding protein -
SULO_RS13365 (SULO_13400) 2398395..2398925 - 531 WP_009988460.1 hemerythrin domain-containing protein -
SULO_RS13370 (SULO_13405) 2399047..2399322 + 276 WP_009988461.1 hypothetical protein -
SULO_RS13375 (SULO_13410) 2399612..2400226 - 615 WP_009988462.1 helix-turn-helix domain-containing protein Toxin
SULO_RS13380 (SULO_13415) 2400244..2400591 - 348 WP_009988464.1 DUF488 domain-containing protein Antitoxin
SULO_RS13385 (SULO_13420) 2400661..2400891 - 231 WP_009988466.1 C2H2-type zinc finger protein -
SULO_RS13390 (SULO_13425) 2400984..2401373 + 390 WP_009988467.1 metal-sulfur cluster assembly factor -
SULO_RS13395 (SULO_13430) 2401366..2401797 - 432 WP_009988468.1 universal stress protein -
SULO_RS13400 (SULO_13435) 2402060..2403019 + 960 WP_010923364.1 IS5-like element ISC1234 family transposase -
SULO_RS13405 (SULO_13440) 2403456..2404388 - 933 WP_009988516.1 dipeptidase -
SULO_RS13410 (SULO_13445) 2404333..2405529 - 1197 WP_009988517.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2402060..2403019 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T113466 WP_009988462.1 NZ_CP033240:c2400226-2399612 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T113466 NZ_CP033240:c2400226-2399612 [Saccharolobus solfataricus]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT113466 WP_009988464.1 NZ_CP033240:c2400591-2400244 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT113466 NZ_CP033240:c2400591-2400244 [Saccharolobus solfataricus]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3MDP8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3GU05

References