Detailed information of TA system TA113464

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2138828..2139515
• Replicon: chromosome
• Accession: NZ_CP033240
• Organism: Saccharolobus solfataricus strain SARC-O

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SULO_RS11965
• Protein ID: WP_231918326.1
• Coordinates: 2139180..2139515 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SULO_RS11960
• Protein ID: WP_009991659.1
• Coordinates: 2138828..2139130 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULO_RS11940 (SULO_11950)	2134752..2135295	-	544	Protein_2311	IS607 family transposase	-
SULO_RS11945 (SULO_11955)	2135623..2136290	+	668	Protein_2312	ISNCY family transposase	-
SULO_RS11950 (SULO_11960)	2136699..2137271	-	573	WP_010923431.1	metallophosphoesterase	-
SULO_RS11955 (SULO_11965)	2137287..2138299	-	1013	Protein_2314	IS630-like element ISC1078 family transposase	-
SULO_RS11960 (SULO_11970)	2138828..2139130	+	303	WP_009991659.1	hypothetical protein	Antitoxin
SULO_RS11965 (SULO_11975)	2139180..2139515	+	336	WP_231918326.1	type II toxin-antitoxin system VapC family toxin	Toxin
SULO_RS11970 (SULO_11980)	2139723..2140838	+	1116	WP_009991657.1	hypothetical protein	-
SULO_RS11975 (SULO_11985)	2140982..2141317	-	336	Protein_2318	transposase	-
SULO_RS11980 (SULO_11990)	2141499..2141644	-	146	Protein_2319	IS630 family transposase	-
SULO_RS15300	2141589..2141780	+	192	WP_048056702.1	hypothetical protein	-
SULO_RS11990 (SULO_12000)	2142040..2142537	-	498	WP_014511660.1	hypothetical protein	-
SULO_RS11995 (SULO_12005)	2142679..2143652	-	974	Protein_2322	IS5 family transposase	-
SULO_RS12000 (SULO_12010)	2143777..2144115	+	339	WP_010923427.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2098036..2311605	213569
	-	inside	IScluster/Tn	-	-	2133518..2147294	13776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-104)

Antitoxin

• Putative antitoxin VapB3-like (28-100)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12427.61 Da
• Isoelectric Point: 5.2389

>T113464 WP_231918326.1 NZ_CP033240:2139180-2139515 [Saccharolobus solfataricus]
IREILKDAETLDFALVEVSNVVWKKAVLTGELTGKDVIKAITIVKEYLPQLLTVNKSIDLIERAIEISVNEKITVYDSLY
IALAECKGSKLVTGDKKQYDVAKKYVISELI

Nucleotide

• Length: 336 bp

>T113464 NZ_CP033240:2139180-2139515 [Saccharolobus solfataricus]
ATTAGAGAGATTTTGAAAGACGCTGAGACATTAGACTTCGCATTAGTGGAAGTATCTAACGTAGTATGGAAGAAAGCTGT
ATTAACTGGGGAATTAACTGGGAAAGATGTAATTAAGGCAATTACTATTGTTAAAGAGTATTTACCACAACTGCTTACAG
TTAACAAAAGCATTGACTTAATTGAAAGAGCTATTGAGATTTCCGTTAACGAGAAAATCACAGTATATGATTCACTTTAT
ATTGCACTGGCTGAATGTAAGGGGAGTAAATTGGTAACGGGGGATAAGAAACAATACGACGTAGCTAAAAAGTACGTCAT
CTCTGAGCTCATATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12195.09 Da
• Isoelectric Point: 4.8275

>AT113464 WP_009991659.1 NZ_CP033240:2138828-2139130 [Saccharolobus solfataricus]
MVIKNATILIYVPEIETFIFPVYVYYNMKTVYSLRLDKELREEMEKYNVKWNEEIESFIRKRIEELKKEEILKKINEILQ
TMPETKSNSADLVREDRDNN

Nucleotide

• Length: 303 bp

>AT113464 NZ_CP033240:2138828-2139130 [Saccharolobus solfataricus]
ATGGTAATAAAGAATGCTACAATTTTAATCTATGTACCAGAGATAGAAACGTTTATATTTCCCGTATACGTGTATTATAA
TATGAAAACCGTATACAGTTTAAGGTTAGATAAGGAATTACGTGAGGAGATGGAGAAATATAACGTCAAGTGGAATGAGG
AGATAGAGAGCTTTATAAGAAAGAGAATTGAGGAATTGAAGAAAGAGGAGATCTTAAAGAAGATTAATGAAATCCTCCAA
ACAATGCCAGAAACTAAGTCAAATAGTGCAGATTTGGTGAGGGAAGATAGGGATAATAATTGA