Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 768075..768681 Replicon chromosome
Accession NZ_CP033240
Organism Saccharolobus solfataricus strain SARC-O

Toxin (Protein)


Gene name vapC Uniprot ID Q97UE3
Locus tag SULO_RS04170 Protein ID WP_009989090.1
Coordinates 768075..768479 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9UBQ9
Locus tag SULO_RS04175 Protein ID WP_009989091.1
Coordinates 768460..768681 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULO_RS04135 (SULO_04140) 763577..764338 - 762 WP_009990867.1 ZIP family metal transporter -
SULO_RS04140 (SULO_04145) 764486..764668 - 183 WP_009990866.1 hypothetical protein -
SULO_RS04150 (SULO_04155) 765504..766283 + 780 WP_014511459.1 DMT family transporter -
SULO_RS04155 (SULO_04160) 766721..767445 + 725 Protein_818 transposase -
SULO_RS04160 (SULO_04165) 767443..767550 - 108 Protein_819 IS110 family transposase -
SULO_RS04165 (SULO_04170) 767592..767879 + 288 WP_272898411.1 transposase -
SULO_RS04170 (SULO_04175) 768075..768479 - 405 WP_009989090.1 PIN domain-containing protein Toxin
SULO_RS04175 (SULO_04180) 768460..768681 - 222 WP_009989091.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SULO_RS04180 (SULO_04185) 769210..769410 + 201 WP_009989095.1 hypothetical protein -
SULO_RS04185 (SULO_04190) 769464..769694 + 231 WP_009989096.1 EamA family transporter -
SULO_RS04190 (SULO_04195) 769805..771076 + 1272 WP_009989097.1 MFS transporter -
SULO_RS04195 (SULO_04200) 771195..771860 + 666 WP_009989098.1 helix-turn-helix domain-containing protein -
SULO_RS04200 (SULO_04205) 771857..772243 - 387 WP_009989099.1 hypothetical protein -
SULO_RS04205 (SULO_04210) 772240..772857 - 618 WP_009989100.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15426.98 Da        Isoelectric Point: 5.0272

>T113462 WP_009989090.1 NZ_CP033240:c768479-768075 [Saccharolobus solfataricus]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLNKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS

Download         Length: 405 bp

>T113462 NZ_CP033240:c768479-768075 [Saccharolobus solfataricus]
GTGGAGAAGGCAATAGTTGACACTAACGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCGGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTGGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATATTAGAAGTGAGAAAGCTGAGGTTGTCTGCGATTGTACAGATAACGTC
ACTGACGCTATAGGAGTGCTGAATAAGGAAAAGCTTCCCTTGGTCAGCTACAAAGATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGAAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTGCTACAGT
CGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8267.50 Da        Isoelectric Point: 9.6908

>AT113462 WP_009989091.1 NZ_CP033240:c768681-768460 [Saccharolobus solfataricus]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS

Download         Length: 222 bp

>AT113462 NZ_CP033240:c768681-768460 [Saccharolobus solfataricus]
ATGGAGAGGGTAAAGGTTACGAGAAATTACCAGATAACTATTCCAGCCTCGGCTAGGAGTAAGATTAATATAAAAGAAGG
AGATATACTTGAGGTTTACTTGAACGGTGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAG
GCAGTAAACTCTCACTGGGAGATATTGAGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3K068

Antitoxin

Source ID Structure
AlphaFold DB M9UBQ9

References