113459

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2398611..2399590 Replicon chromosome
Accession NZ_CP033239
Organism Saccharolobus solfataricus strain SARC-N

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SULN_RS13370 Protein ID WP_009988462.1
Coordinates 2398611..2399225 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SULN_RS13375 Protein ID WP_009988464.1
Coordinates 2399243..2399590 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULN_RS13340 (SULN_13360) 2394627..2395226 - 600 WP_009991466.1 DUF2249 domain-containing protein -
SULN_RS13345 (SULN_13365) 2395953..2396195 + 243 WP_009988456.1 hypothetical protein -
SULN_RS13350 (SULN_13370) 2396176..2396520 - 345 WP_009988458.1 hypothetical protein -
SULN_RS13355 (SULN_13375) 2396524..2397288 - 765 WP_009988459.1 plastocyanin/azurin family copper-binding protein -
SULN_RS13360 (SULN_13380) 2397394..2397924 - 531 WP_009988460.1 hemerythrin domain-containing protein -
SULN_RS13365 (SULN_13385) 2398046..2398321 + 276 WP_009988461.1 hypothetical protein -
SULN_RS13370 (SULN_13390) 2398611..2399225 - 615 WP_009988462.1 helix-turn-helix domain-containing protein Toxin
SULN_RS13375 (SULN_13395) 2399243..2399590 - 348 WP_009988464.1 DUF488 domain-containing protein Antitoxin
SULN_RS13380 (SULN_13400) 2399660..2399890 - 231 WP_009988466.1 C2H2-type zinc finger protein -
SULN_RS13385 (SULN_13405) 2399983..2400372 + 390 WP_009988467.1 metal-sulfur cluster assembly factor -
SULN_RS13390 (SULN_13410) 2400365..2400796 - 432 WP_009988468.1 universal stress protein -
SULN_RS13395 (SULN_13415) 2401059..2402018 + 960 WP_010923364.1 IS5-like element ISC1234 family transposase -
SULN_RS13400 (SULN_13420) 2402455..2403387 - 933 WP_009988516.1 dipeptidase -
SULN_RS13405 (SULN_13425) 2403332..2404528 - 1197 WP_009988517.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2401059..2402018 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T113459 WP_009988462.1 NZ_CP033239:c2399225-2398611 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T113459 NZ_CP033239:c2399225-2398611 [Saccharolobus solfataricus]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT113459 WP_009988464.1 NZ_CP033239:c2399590-2399243 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT113459 NZ_CP033239:c2399590-2399243 [Saccharolobus solfataricus]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3MDP8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3GU05

References