Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2527901..2528507 | Replicon | chromosome |
| Accession | NZ_CP033238 | ||
| Organism | Saccharolobus solfataricus strain SULM | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q97WY9 |
| Locus tag | SULM_RS14145 | Protein ID | WP_009991922.1 |
| Coordinates | 2528115..2528507 (+) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | C3NC15 |
| Locus tag | SULM_RS14140 | Protein ID | WP_009991920.1 |
| Coordinates | 2527901..2528125 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SULM_RS14105 (SULM_14145) | 2523145..2524086 | - | 942 | WP_124405879.1 | IS110 family transposase | - |
| SULM_RS14110 (SULM_14150) | 2524245..2524529 | + | 285 | Protein_2737 | IS607-like element ISC1913 family transposase | - |
| SULM_RS14115 (SULM_14155) | 2524513..2525733 | + | 1221 | WP_014511730.1 | IS200/IS605 family accessory protein TnpB-related protein | - |
| SULM_RS14120 (SULM_14160) | 2525881..2526267 | - | 387 | WP_009991912.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULM_RS14125 (SULM_14165) | 2526254..2526529 | - | 276 | WP_009991915.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SULM_RS14130 (SULM_14170) | 2526900..2527136 | + | 237 | WP_009991916.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SULM_RS14135 (SULM_14175) | 2527114..2527512 | + | 399 | WP_009991918.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULM_RS14140 (SULM_14180) | 2527901..2528125 | + | 225 | WP_009991920.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| SULM_RS14145 (SULM_14185) | 2528115..2528507 | + | 393 | WP_009991922.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SULM_RS14150 (SULM_14190) | 2528681..2529631 | + | 951 | WP_010923701.1 | IS110 family transposase | - |
| SULM_RS14155 (SULM_14195) | 2529705..2530754 | - | 1050 | Protein_2746 | AMP-binding protein | - |
| SULM_RS14160 (SULM_14200) | 2530855..2531970 | + | 1116 | WP_009988843.1 | acyl-CoA dehydrogenase family protein | - |
| SULM_RS14165 (SULM_14205) | 2532033..2533178 | + | 1146 | WP_009988841.1 | thiolase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 2509791..2529631 | 19840 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 15105.86 Da Isoelectric Point: 8.2957
>T113454 WP_009991922.1 NZ_CP033238:2528115-2528507 [Saccharolobus solfataricus]
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
Download Length: 393 bp
>T113454 NZ_CP033238:2528115-2528507 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8881.24 Da Isoelectric Point: 5.0355
>AT113454 WP_009991920.1 NZ_CP033238:2527901-2528125 [Saccharolobus solfataricus]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
Download Length: 225 bp
>AT113454 NZ_CP033238:2527901-2528125 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3K6Y2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3MHL6 |