Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 2525881..2526529 Replicon chromosome
Accession NZ_CP033238
Organism Saccharolobus solfataricus strain SULM

Toxin (Protein)


Gene name vapC Uniprot ID Q97WZ2
Locus tag SULM_RS14120 Protein ID WP_009991912.1
Coordinates 2525881..2526267 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97WZ1
Locus tag SULM_RS14125 Protein ID WP_009991915.1
Coordinates 2526254..2526529 (-) Length 92 a.a.

Genomic Context

SULM_RS14110SULM_RS14115SULM_RS14130SULM_RS14135SULM_RS14140SULM_RS14145SULM_RS14150SULM_RS14090SULM_RS14100SULM_RS14105SULM_RS14120SULM_RS14125SULM_RS14155
Location: 2524245..2524529 (285 bp)
Type: Others
Protein ID: Protein_2737
Location: 2524513..2525733 (1221 bp)
Type: Others
Protein ID: WP_014511730.1
Location: 2526900..2527136 (237 bp)
Type: Others
Protein ID: WP_009991916.1
Location: 2527114..2527512 (399 bp)
Type: Others
Protein ID: WP_009991918.1
Location: 2527901..2528125 (225 bp)
Type: Others
Protein ID: WP_009991920.1
Location: 2528115..2528507 (393 bp)
Type: Others
Protein ID: WP_009991922.1
Location: 2528681..2529631 (951 bp)
Type: Others
Protein ID: WP_010923701.1
Location: 2520926..2521930 (1005 bp)
Type: Others
Protein ID: WP_009989083.1
Location: 2522235..2523176 (942 bp)
Type: Others
Protein ID: WP_124405881.1
Location: 2523145..2524086 (942 bp)
Type: Others
Protein ID: WP_124405879.1
Location: 2525881..2526267 (387 bp)
Type: Toxin
Protein ID: WP_009991912.1
Location: 2526254..2526529 (276 bp)
Type: Antitoxin
Protein ID: WP_009991915.1
Location: 2529705..2530754 (1050 bp)
Type: Others
Protein ID: Protein_2746
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULM_RS14090 (SULM_14130)2520926..2521930-1005WP_009989083.1endoglucanase-
SULM_RS14100 (SULM_14140)2522235..2523176-942WP_124405881.1IS110 family transposase-
SULM_RS14105 (SULM_14145)2523145..2524086-942WP_124405879.1IS110 family transposase-
SULM_RS14110 (SULM_14150)2524245..2524529+285Protein_2737IS607-like element ISC1913 family transposase-
SULM_RS14115 (SULM_14155)2524513..2525733+1221WP_014511730.1IS200/IS605 family accessory protein TnpB-related protein-
SULM_RS14120 (SULM_14160)2525881..2526267-387WP_009991912.1type II toxin-antitoxin system VapC family toxinToxin
SULM_RS14125 (SULM_14165)2526254..2526529-276WP_009991915.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SULM_RS14130 (SULM_14170)2526900..2527136+237WP_009991916.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
SULM_RS14135 (SULM_14175)2527114..2527512+399WP_009991918.1type II toxin-antitoxin system VapC family toxin-
SULM_RS14140 (SULM_14180)2527901..2528125+225WP_009991920.1type II toxin-antitoxin system CcdA family antitoxin-
SULM_RS14145 (SULM_14185)2528115..2528507+393WP_009991922.1type II toxin-antitoxin system VapC family toxin-
SULM_RS14150 (SULM_14190)2528681..2529631+951WP_010923701.1IS110 family transposase-
SULM_RS14155 (SULM_14195)2529705..2530754-1050Protein_2746AMP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIScluster/Tn--2509791..252963119840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 15042.69 Da        Isoelectric Point: 4.9844

>T113453 WP_009991912.1 NZ_CP033238:c2526267-2525881 [Saccharolobus solfataricus]
MIFLDANFLIYLNSGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVKPSDAFHIAVMLNNSINVILSEDKELDKVAEIKRIWI

Download         Length: 387 bp

>T113453 NZ_CP033238:c2526267-2525881 [Saccharolobus solfataricus]
TTGATTTTTCTTGATGCTAATTTCTTAATCTACTTAAACTCGGGTGTAAGTGAGGTAAAAGAGTATTATATAAAACTCCT
CACATATGAAAGCTTGTTTTCAGATCCTTTAGTTATAGATGAGGTAATATACGTGTCTAAGAAGAAGTATGGAGTTAAGT
ATTGCGATACCATAGAATTCTTGGATGAAATAGTGCTCAAGTACTTAACAGTTTTACCAATCACGATAAAGGAATATGAG
AGGGCTAAAGAAATTATGAGAAAATACTCAGTTAAGCCATCTGATGCCTTTCATATTGCCGTAATGTTAAACAATTCAAT
AAACGTGATCTTAAGTGAAGATAAGGAGTTAGATAAAGTTGCAGAAATAAAGAGAATATGGATTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10372.22 Da        Isoelectric Point: 7.0185

>AT113453 WP_009991915.1 NZ_CP033238:c2526529-2526254 [Saccharolobus solfataricus]
MSLTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENI
SLEEELKIDFS

Download         Length: 276 bp

>AT113453 NZ_CP033238:c2526529-2526254 [Saccharolobus solfataricus]
ATGAGTTTGACTCTAAGAGTGGAAGTTGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAAT
AAAAGAGGGGGATATCTTAATTTTGACAGTCGTTGGAGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAG
AAGTTGTCAAAAAATTAGAAGAACATGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATA
AGTCTTGAAGAGGAATTGAAGATTGATTTTTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3KDP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3MDU1

References