Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2398611..2399590 Replicon chromosome
Accession NZ_CP033238
Organism Saccharolobus solfataricus strain SULM

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SULM_RS13365 Protein ID WP_009988462.1
Coordinates 2398611..2399225 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SULM_RS13370 Protein ID WP_009988464.1
Coordinates 2399243..2399590 (-) Length 116 a.a.

Genomic Context

SULM_RS13340SULM_RS13360SULM_RS13380SULM_RS13390SULM_RS13335SULM_RS13345SULM_RS13350SULM_RS13355SULM_RS13365SULM_RS13370SULM_RS13375SULM_RS13385SULM_RS13395SULM_RS13400
Location: 2395953..2396195 (243 bp)
Type: Others
Protein ID: WP_009988456.1
Location: 2398046..2398321 (276 bp)
Type: Others
Protein ID: WP_009988461.1
Location: 2399983..2400372 (390 bp)
Type: Others
Protein ID: WP_009988467.1
Location: 2401059..2402018 (960 bp)
Type: Others
Protein ID: WP_010923364.1
Location: 2394627..2395226 (600 bp)
Type: Others
Protein ID: WP_009991466.1
Location: 2396176..2396520 (345 bp)
Type: Others
Protein ID: WP_009988458.1
Location: 2396524..2397288 (765 bp)
Type: Others
Protein ID: WP_009988459.1
Location: 2397394..2397924 (531 bp)
Type: Others
Protein ID: WP_009988460.1
Location: 2398611..2399225 (615 bp)
Type: Toxin
Protein ID: WP_009988462.1
Location: 2399243..2399590 (348 bp)
Type: Antitoxin
Protein ID: WP_009988464.1
Location: 2399660..2399890 (231 bp)
Type: Others
Protein ID: WP_009988466.1
Location: 2400365..2400796 (432 bp)
Type: Others
Protein ID: WP_009988468.1
Location: 2402455..2403387 (933 bp)
Type: Others
Protein ID: WP_009988516.1
Location: 2403332..2404528 (1197 bp)
Type: Others
Protein ID: WP_009988517.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULM_RS13335 (SULM_13370)2394627..2395226-600WP_009991466.1DUF2249 domain-containing protein-
SULM_RS13340 (SULM_13375)2395953..2396195+243WP_009988456.1hypothetical protein-
SULM_RS13345 (SULM_13380)2396176..2396520-345WP_009988458.1hypothetical protein-
SULM_RS13350 (SULM_13385)2396524..2397288-765WP_009988459.1plastocyanin/azurin family copper-binding protein-
SULM_RS13355 (SULM_13390)2397394..2397924-531WP_009988460.1hemerythrin domain-containing protein-
SULM_RS13360 (SULM_13395)2398046..2398321+276WP_009988461.1hypothetical protein-
SULM_RS13365 (SULM_13400)2398611..2399225-615WP_009988462.1helix-turn-helix domain-containing proteinToxin
SULM_RS13370 (SULM_13405)2399243..2399590-348WP_009988464.1DUF488 domain-containing proteinAntitoxin
SULM_RS13375 (SULM_13410)2399660..2399890-231WP_009988466.1C2H2-type zinc finger protein-
SULM_RS13380 (SULM_13415)2399983..2400372+390WP_009988467.1metal-sulfur cluster assembly factor-
SULM_RS13385 (SULM_13420)2400365..2400796-432WP_009988468.1universal stress protein-
SULM_RS13390 (SULM_13425)2401059..2402018+960WP_010923364.1IS5-like element ISC1234 family transposase-
SULM_RS13395 (SULM_13430)2402455..2403387-933WP_009988516.1dipeptidase-
SULM_RS13400 (SULM_13435)2403332..2404528-1197WP_009988517.1MFS transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--2401059..2402018959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T113452 WP_009988462.1 NZ_CP033238:c2399225-2398611 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T113452 NZ_CP033238:c2399225-2398611 [Saccharolobus solfataricus]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT113452 WP_009988464.1 NZ_CP033238:c2399590-2399243 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT113452 NZ_CP033238:c2399590-2399243 [Saccharolobus solfataricus]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3MDP8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3GU05

References