Detailed information of TA system TA113451

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 2344260..2344907
• Replicon: chromosome
• Accession: NZ_CP033238
• Organism: Saccharolobus solfataricus strain SULM

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SULM_RS13025
• Protein ID: WP_009990357.1
• Coordinates: 2344260..2344532 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0E3K976
• Locus tag: SULM_RS13030
• Protein ID: WP_009990356.1
• Coordinates: 2344647..2344907 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULM_RS13000 (SULM_13030)	2339575..2340626	-	1052	Protein_2521	ISH3-like element ISC1359 family transposase	-
SULM_RS13005 (SULM_13035)	2340730..2341479	+	750	Protein_2522	GDP-mannose 4,6-dehydratase	-
SULM_RS13015 (SULM_13050)	2342790..2343737	-	948	WP_009990359.1	ATP/GTP-binding protein	-
SULM_RS13025 (SULM_13060)	2344260..2344532	-	273	WP_009990357.1	PIN domain-containing protein	Toxin
SULM_RS13030 (SULM_13065)	2344647..2344907	-	261	WP_009990356.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SULM_RS13035 (SULM_13070)	2345594..2345755	+	162	WP_009990355.1	hypothetical protein	-
SULM_RS13040 (SULM_13075)	2345857..2346315	+	459	WP_009990354.1	hypothetical protein	-
SULM_RS13045 (SULM_13080)	2347064..2347570	-	507	WP_014511696.1	thiosulfate:quinone oxidoreductase small subunit	-
SULM_RS13050 (SULM_13085)	2347576..2348118	-	543	WP_009990352.1	thiosulfate:quinone oxidoreductase large subunit	-
SULM_RS13055 (SULM_13090)	2348426..2349301	-	876	Protein_2530	transposase	-
SULM_RS13060 (SULM_13095)	2349662..2349895	+	234	WP_009993269.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (20-82)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10475.34 Da
• Isoelectric Point: 9.7534

>T113451 WP_009990357.1 NZ_CP033238:c2344532-2344260 [Saccharolobus solfataricus]
MRLFTLSKKKYNVKFEDTIDFLDKIILPYTIILPINSHDYEKAKGIMISKTLKPSDAFHVAVMINNSIKKIVSEDSDFDK
INGIERIWVK

Nucleotide

• Length: 273 bp

>T113451 NZ_CP033238:c2344532-2344260 [Saccharolobus solfataricus]
ATGAGGTTATTTACATTATCAAAAAAGAAGTATAATGTAAAATTTGAGGATACAATTGATTTCTTAGATAAGATAATACT
TCCTTATACAATTATACTGCCAATCAACTCTCATGATTATGAAAAAGCAAAGGGGATAATGATAAGTAAGACTTTAAAAC
CGTCTGATGCTTTCCACGTAGCTGTAATGATAAATAATTCAATAAAAAAGATAGTAAGTGAGGATTCAGATTTCGATAAA
ATTAATGGAATAGAAAGGATTTGGGTAAAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9842.51 Da
• Isoelectric Point: 5.2456

>AT113451 WP_009990356.1 NZ_CP033238:c2344907-2344647 [Saccharolobus solfataricus]
MTLKIEVGKKGYIIIPKTVRDLLEIKEGDILILRVEDGKIVLEPERKVSFDDLKKKMEEHSAKISYANKAKLGDLINVSL
EEEFDN

Nucleotide

• Length: 261 bp

>AT113451 NZ_CP033238:c2344907-2344647 [Saccharolobus solfataricus]
TTGACCCTAAAGATTGAAGTTGGAAAGAAAGGATATATAATAATCCCTAAGACTGTTAGGGATCTTCTTGAAATAAAGGA
GGGAGATATATTAATCCTAAGAGTCGAAGATGGTAAAATTGTTCTTGAGCCTGAAAGAAAGGTAAGTTTTGATGACTTAA
AAAAGAAGATGGAGGAACATAGTGCTAAAATCTCATATGCAAATAAGGCTAAACTTGGAGATTTAATTAACGTTAGTTTA
GAGGAGGAATTCGATAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E3K976