Detailed information of TA system TA113450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2137827..2138514
• Replicon: chromosome
• Accession: NZ_CP033238
• Organism: Saccharolobus solfataricus strain SULM

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SULM_RS11955
• Protein ID: WP_231918326.1
• Coordinates: 2138179..2138514 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SULM_RS11950
• Protein ID: WP_009991659.1
• Coordinates: 2137827..2138129 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULM_RS11930 (SULM_11940)	2133751..2134294	-	544	Protein_2308	IS607 family transposase	-
SULM_RS11935 (SULM_11945)	2134622..2135289	+	668	Protein_2309	ISNCY family transposase	-
SULM_RS11940 (SULM_11950)	2135698..2136270	-	573	WP_010923431.1	metallophosphoesterase	-
SULM_RS11945 (SULM_11955)	2136286..2137298	-	1013	Protein_2311	IS630-like element ISC1078 family transposase	-
SULM_RS11950 (SULM_11960)	2137827..2138129	+	303	WP_009991659.1	hypothetical protein	Antitoxin
SULM_RS11955 (SULM_11965)	2138179..2138514	+	336	WP_231918326.1	type II toxin-antitoxin system VapC family toxin	Toxin
SULM_RS11960 (SULM_11970)	2138722..2139837	+	1116	WP_009991657.1	hypothetical protein	-
SULM_RS11965 (SULM_11975)	2139981..2140316	-	336	Protein_2315	transposase	-
SULM_RS11970 (SULM_11980)	2140498..2140643	-	146	Protein_2316	IS630 family transposase	-
SULM_RS15290	2140588..2140779	+	192	WP_048056702.1	hypothetical protein	-
SULM_RS11980 (SULM_11990)	2141039..2141536	-	498	WP_014511660.1	hypothetical protein	-
SULM_RS11985 (SULM_11995)	2141678..2142651	-	974	Protein_2319	IS5 family transposase	-
SULM_RS11990 (SULM_12000)	2142776..2143114	+	339	WP_010923427.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2097035..2310604	213569
	-	inside	IScluster/Tn	-	-	2132517..2146293	13776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-104)

Antitoxin

• Putative antitoxin VapB3-like (28-100)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12427.61 Da
• Isoelectric Point: 5.2389

>T113450 WP_231918326.1 NZ_CP033238:2138179-2138514 [Saccharolobus solfataricus]
IREILKDAETLDFALVEVSNVVWKKAVLTGELTGKDVIKAITIVKEYLPQLLTVNKSIDLIERAIEISVNEKITVYDSLY
IALAECKGSKLVTGDKKQYDVAKKYVISELI

Nucleotide

• Length: 336 bp

>T113450 NZ_CP033238:2138179-2138514 [Saccharolobus solfataricus]
ATTAGAGAGATTTTGAAAGACGCTGAGACATTAGACTTCGCATTAGTGGAAGTATCTAACGTAGTATGGAAGAAAGCTGT
ATTAACTGGGGAATTAACTGGGAAAGATGTAATTAAGGCAATTACTATTGTTAAAGAGTATTTACCACAACTGCTTACAG
TTAACAAAAGCATTGACTTAATTGAAAGAGCTATTGAGATTTCCGTTAACGAGAAAATCACAGTATATGATTCACTTTAT
ATTGCACTGGCTGAATGTAAGGGGAGTAAATTGGTAACGGGGGATAAGAAACAATACGACGTAGCTAAAAAGTACGTCAT
CTCTGAGCTCATATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12195.09 Da
• Isoelectric Point: 4.8275

>AT113450 WP_009991659.1 NZ_CP033238:2137827-2138129 [Saccharolobus solfataricus]
MVIKNATILIYVPEIETFIFPVYVYYNMKTVYSLRLDKELREEMEKYNVKWNEEIESFIRKRIEELKKEEILKKINEILQ
TMPETKSNSADLVREDRDNN

Nucleotide

• Length: 303 bp

>AT113450 NZ_CP033238:2137827-2138129 [Saccharolobus solfataricus]
ATGGTAATAAAGAATGCTACAATTTTAATCTATGTACCAGAGATAGAAACGTTTATATTTCCCGTATACGTGTATTATAA
TATGAAAACCGTATACAGTTTAAGGTTAGATAAGGAATTACGTGAGGAGATGGAGAAATATAACGTCAAGTGGAATGAGG
AGATAGAGAGCTTTATAAGAAAGAGAATTGAGGAATTGAAGAAAGAGGAGATCTTAAAGAAGATTAATGAAATCCTCCAA
ACAATGCCAGAAACTAAGTCAAATAGTGCAGATTTGGTGAGGGAAGATAGGGATAATAATTGA