Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1984272..1984878 Replicon chromosome
Accession NZ_CP033238
Organism Saccharolobus solfataricus strain SULM

Toxin (Protein)


Gene name vapC Uniprot ID Q97YS3
Locus tag SULM_RS11295 Protein ID WP_009993017.1
Coordinates 1984486..1984878 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E3MAZ1
Locus tag SULM_RS11290 Protein ID WP_014511634.1
Coordinates 1984272..1984496 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULM_RS11265 (SULM_11270) 1979420..1980550 + 1131 WP_009992604.1 aromatic/alkene monooxygenase hydroxylase subunit beta -
SULM_RS11270 (SULM_11275) 1980547..1981008 + 462 WP_010923265.1 metal-sulfur cluster assembly factor -
SULM_RS11275 (SULM_11280) 1981051..1981966 - 916 Protein_2182 IS110 family transposase -
SULM_RS11280 (SULM_11285) 1982011..1982994 + 984 WP_010923242.1 IS630-like element ISC1048 family transposase -
SULM_RS11285 (SULM_11290) 1982993..1983962 + 970 Protein_2184 IS110 family transposase -
SULM_RS11290 (SULM_11295) 1984272..1984496 + 225 WP_014511634.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SULM_RS11295 (SULM_11300) 1984486..1984878 + 393 WP_009993017.1 type II toxin-antitoxin system VapC family toxin Toxin
SULM_RS11300 (SULM_11305) 1985321..1985799 - 479 Protein_2187 ISNCY family transposase -
SULM_RS11305 (SULM_11310) 1985917..1986969 + 1053 WP_010923271.1 ISH3 family transposase -
SULM_RS11310 (SULM_11315) 1987157..1987744 - 588 Protein_2189 ISNCY family transposase -
SULM_RS11315 (SULM_11320) 1988178..1988519 - 342 WP_009990179.1 nucleotidyltransferase domain-containing protein -
SULM_RS11320 (SULM_11325) 1988510..1988857 - 348 WP_014511635.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1975995..1987744 11749
- inside IScluster/Tn - - 1975150..1987744 12594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-49)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15117.81 Da        Isoelectric Point: 9.3474

>T113449 WP_009993017.1 NZ_CP033238:1984486-1984878 [Saccharolobus solfataricus]
MKDKEFLLDASALYSLLDYVDKVDVKKIHVLTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVIEDSPLEGV
MRIAIERGLTYYNASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T113449 NZ_CP033238:1984486-1984878 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCTTGCTCGATGCCTCAGCTTTGTATTCACTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATGTACTTACCCTAACTTTTTATGAGGTAGGTAATGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCTATAAATTAATGCGAAAATTTAACGTAATAGAGGATTCGCCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATAACGCATCTTATGCGTATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAACGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8792.11 Da        Isoelectric Point: 4.8365

>AT113449 WP_014511634.1 NZ_CP033238:1984272-1984496 [Saccharolobus solfataricus]
MSDVISVRVKKELKKKAEELGINVREVVEKALEEAIREKEKEELKDMTMKIKELMRDVSEDDWVSTVRESRDER

Download         Length: 225 bp

>AT113449 NZ_CP033238:1984272-1984496 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGAGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTAGGAATTAACGTTAGGGAAGT
TGTAGAAAAAGCTTTAGAGGAAGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGACTATGAAAATTAAGGAAC
TAATGAGGGACGTAAGTGAAGATGATTGGGTAAGTACTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3GVD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3MAZ1

References