Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1984272..1984878 Replicon chromosome
Accession NZ_CP033238
Organism Saccharolobus solfataricus strain SULM

Toxin (Protein)


Gene name vapC Uniprot ID Q97YS3
Locus tag SULM_RS11295 Protein ID WP_009993017.1
Coordinates 1984486..1984878 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E3MAZ1
Locus tag SULM_RS11290 Protein ID WP_014511634.1
Coordinates 1984272..1984496 (+) Length 75 a.a.

Genomic Context

SULM_RS11265SULM_RS11270SULM_RS11280SULM_RS11285SULM_RS11290SULM_RS11295SULM_RS11305SULM_RS11275SULM_RS11300SULM_RS11310SULM_RS11315SULM_RS11320
Location: 1979420..1980550 (1131 bp)
Type: Others
Protein ID: WP_009992604.1
Location: 1980547..1981008 (462 bp)
Type: Others
Protein ID: WP_010923265.1
Location: 1982011..1982994 (984 bp)
Type: Others
Protein ID: WP_010923242.1
Location: 1982993..1983962 (970 bp)
Type: Others
Protein ID: Protein_2184
Location: 1984272..1984496 (225 bp)
Type: Antitoxin
Protein ID: WP_014511634.1
Location: 1984486..1984878 (393 bp)
Type: Toxin
Protein ID: WP_009993017.1
Location: 1985917..1986969 (1053 bp)
Type: Others
Protein ID: WP_010923271.1
Location: 1981051..1981966 (916 bp)
Type: Others
Protein ID: Protein_2182
Location: 1985321..1985799 (479 bp)
Type: Others
Protein ID: Protein_2187
Location: 1987157..1987744 (588 bp)
Type: Others
Protein ID: Protein_2189
Location: 1988178..1988519 (342 bp)
Type: Others
Protein ID: WP_009990179.1
Location: 1988510..1988857 (348 bp)
Type: Others
Protein ID: WP_014511635.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULM_RS11265 (SULM_11270)1979420..1980550+1131WP_009992604.1aromatic/alkene monooxygenase hydroxylase subunit beta-
SULM_RS11270 (SULM_11275)1980547..1981008+462WP_010923265.1metal-sulfur cluster assembly factor-
SULM_RS11275 (SULM_11280)1981051..1981966-916Protein_2182IS110 family transposase-
SULM_RS11280 (SULM_11285)1982011..1982994+984WP_010923242.1IS630-like element ISC1048 family transposase-
SULM_RS11285 (SULM_11290)1982993..1983962+970Protein_2184IS110 family transposase-
SULM_RS11290 (SULM_11295)1984272..1984496+225WP_014511634.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
SULM_RS11295 (SULM_11300)1984486..1984878+393WP_009993017.1type II toxin-antitoxin system VapC family toxinToxin
SULM_RS11300 (SULM_11305)1985321..1985799-479Protein_2187ISNCY family transposase-
SULM_RS11305 (SULM_11310)1985917..1986969+1053WP_010923271.1ISH3 family transposase-
SULM_RS11310 (SULM_11315)1987157..1987744-588Protein_2189ISNCY family transposase-
SULM_RS11315 (SULM_11320)1988178..1988519-342WP_009990179.1nucleotidyltransferase domain-containing protein-
SULM_RS11320 (SULM_11325)1988510..1988857-348WP_014511635.1HEPN domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1975995..198774411749
-insideIScluster/Tn--1975150..198774412594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-49)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15117.81 Da        Isoelectric Point: 9.3474

>T113449 WP_009993017.1 NZ_CP033238:1984486-1984878 [Saccharolobus solfataricus]
MKDKEFLLDASALYSLLDYVDKVDVKKIHVLTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVIEDSPLEGV
MRIAIERGLTYYNASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T113449 NZ_CP033238:1984486-1984878 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCTTGCTCGATGCCTCAGCTTTGTATTCACTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATGTACTTACCCTAACTTTTTATGAGGTAGGTAATGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCTATAAATTAATGCGAAAATTTAACGTAATAGAGGATTCGCCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATAACGCATCTTATGCGTATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAACGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8792.11 Da        Isoelectric Point: 4.8365

>AT113449 WP_014511634.1 NZ_CP033238:1984272-1984496 [Saccharolobus solfataricus]
MSDVISVRVKKELKKKAEELGINVREVVEKALEEAIREKEKEELKDMTMKIKELMRDVSEDDWVSTVRESRDER

Download         Length: 225 bp

>AT113449 NZ_CP033238:1984272-1984496 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGAGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTAGGAATTAACGTTAGGGAAGT
TGTAGAAAAAGCTTTAGAGGAAGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGACTATGAAAATTAAGGAAC
TAATGAGGGACGTAAGTGAAGATGATTGGGTAAGTACTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3GVD1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3MAZ1

References