Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-AbrB |
| Location | 2536716..2537364 | Replicon | chromosome |
| Accession | NZ_CP033237 | ||
| Organism | Saccharolobus solfataricus strain SARC-I | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q97WZ2 |
| Locus tag | SULI_RS14190 | Protein ID | WP_009991912.1 |
| Coordinates | 2536716..2537102 (-) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | Q97WZ1 |
| Locus tag | SULI_RS14195 | Protein ID | WP_009991915.1 |
| Coordinates | 2537089..2537364 (-) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SULI_RS14160 (SULI_14200) | 2531798..2532571 | - | 774 | WP_009991748.1 | extradiol dioxygenase | - |
| SULI_RS14165 (SULI_14205) | 2532827..2533252 | - | 426 | WP_009991747.1 | DUF4143 domain-containing protein | - |
| SULI_RS14170 (SULI_14210) | 2533539..2533895 | + | 357 | Protein_2750 | IS607 family transposase | - |
| SULI_RS14175 (SULI_14215) | 2533971..2534921 | - | 951 | WP_010923701.1 | IS110 family transposase | - |
| SULI_RS14180 (SULI_14220) | 2535080..2535364 | + | 285 | Protein_2752 | IS607-like element ISC1913 family transposase | - |
| SULI_RS14185 (SULI_14225) | 2535348..2536568 | + | 1221 | WP_014511730.1 | IS200/IS605 family accessory protein TnpB-related protein | - |
| SULI_RS14190 (SULI_14230) | 2536716..2537102 | - | 387 | WP_009991912.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SULI_RS14195 (SULI_14235) | 2537089..2537364 | - | 276 | WP_009991915.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| SULI_RS14200 (SULI_14240) | 2537735..2537971 | + | 237 | WP_009991916.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SULI_RS14205 (SULI_14245) | 2537949..2538347 | + | 399 | WP_009991918.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULI_RS14210 (SULI_14250) | 2538736..2538960 | + | 225 | WP_009991920.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| SULI_RS14215 (SULI_14255) | 2538950..2539342 | + | 393 | WP_009991922.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULI_RS14220 (SULI_14260) | 2539516..2540466 | + | 951 | WP_010923701.1 | IS110 family transposase | - |
| SULI_RS14225 (SULI_14265) | 2540540..2541589 | - | 1050 | Protein_2761 | AMP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 2533539..2540466 | 6927 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 15042.69 Da Isoelectric Point: 4.9844
>T113446 WP_009991912.1 NZ_CP033237:c2537102-2536716 [Saccharolobus solfataricus]
MIFLDANFLIYLNSGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVKPSDAFHIAVMLNNSINVILSEDKELDKVAEIKRIWI
MIFLDANFLIYLNSGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVKPSDAFHIAVMLNNSINVILSEDKELDKVAEIKRIWI
Download Length: 387 bp
>T113446 NZ_CP033237:c2537102-2536716 [Saccharolobus solfataricus]
TTGATTTTTCTTGATGCTAATTTCTTAATCTACTTAAACTCGGGTGTAAGTGAGGTAAAAGAGTATTATATAAAACTCCT
CACATATGAAAGCTTGTTTTCAGATCCTTTAGTTATAGATGAGGTAATATACGTGTCTAAGAAGAAGTATGGAGTTAAGT
ATTGCGATACCATAGAATTCTTGGATGAAATAGTGCTCAAGTACTTAACAGTTTTACCAATCACGATAAAGGAATATGAG
AGGGCTAAAGAAATTATGAGAAAATACTCAGTTAAGCCATCTGATGCCTTTCATATTGCCGTAATGTTAAACAATTCAAT
AAACGTGATCTTAAGTGAAGATAAGGAGTTAGATAAAGTTGCAGAAATAAAGAGAATATGGATTTAA
TTGATTTTTCTTGATGCTAATTTCTTAATCTACTTAAACTCGGGTGTAAGTGAGGTAAAAGAGTATTATATAAAACTCCT
CACATATGAAAGCTTGTTTTCAGATCCTTTAGTTATAGATGAGGTAATATACGTGTCTAAGAAGAAGTATGGAGTTAAGT
ATTGCGATACCATAGAATTCTTGGATGAAATAGTGCTCAAGTACTTAACAGTTTTACCAATCACGATAAAGGAATATGAG
AGGGCTAAAGAAATTATGAGAAAATACTCAGTTAAGCCATCTGATGCCTTTCATATTGCCGTAATGTTAAACAATTCAAT
AAACGTGATCTTAAGTGAAGATAAGGAGTTAGATAAAGTTGCAGAAATAAAGAGAATATGGATTTAA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10372.22 Da Isoelectric Point: 7.0185
>AT113446 WP_009991915.1 NZ_CP033237:c2537364-2537089 [Saccharolobus solfataricus]
MSLTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENI
SLEEELKIDFS
MSLTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENI
SLEEELKIDFS
Download Length: 276 bp
>AT113446 NZ_CP033237:c2537364-2537089 [Saccharolobus solfataricus]
ATGAGTTTGACTCTAAGAGTGGAAGTTGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAAT
AAAAGAGGGGGATATCTTAATTTTGACAGTCGTTGGAGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAG
AAGTTGTCAAAAAATTAGAAGAACATGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATA
AGTCTTGAAGAGGAATTGAAGATTGATTTTTCTTGA
ATGAGTTTGACTCTAAGAGTGGAAGTTGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAAT
AAAAGAGGGGGATATCTTAATTTTGACAGTCGTTGGAGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAG
AAGTTGTCAAAAAATTAGAAGAACATGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATA
AGTCTTGAAGAGGAATTGAAGATTGATTTTTCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3KDP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3MDU1 |