Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2399985..2400964 Replicon chromosome
Accession NZ_CP033237
Organism Saccharolobus solfataricus strain SARC-I

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SULI_RS13375 Protein ID WP_009988462.1
Coordinates 2399985..2400599 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SULI_RS13380 Protein ID WP_009988464.1
Coordinates 2400617..2400964 (-) Length 116 a.a.

Genomic Context

SULI_RS13350SULI_RS13370SULI_RS13390SULI_RS13400SULI_RS13345SULI_RS13355SULI_RS13360SULI_RS13365SULI_RS13375SULI_RS13380SULI_RS13385SULI_RS13395SULI_RS13405SULI_RS13410
Location: 2397327..2397569 (243 bp)
Type: Others
Protein ID: WP_009988456.1
Location: 2399420..2399695 (276 bp)
Type: Others
Protein ID: WP_009988461.1
Location: 2401357..2401746 (390 bp)
Type: Others
Protein ID: WP_009988467.1
Location: 2402433..2403392 (960 bp)
Type: Others
Protein ID: WP_010923364.1
Location: 2396001..2396600 (600 bp)
Type: Others
Protein ID: WP_009991466.1
Location: 2397550..2397894 (345 bp)
Type: Others
Protein ID: WP_009988458.1
Location: 2397898..2398662 (765 bp)
Type: Others
Protein ID: WP_009988459.1
Location: 2398768..2399298 (531 bp)
Type: Others
Protein ID: WP_009988460.1
Location: 2399985..2400599 (615 bp)
Type: Toxin
Protein ID: WP_009988462.1
Location: 2400617..2400964 (348 bp)
Type: Antitoxin
Protein ID: WP_009988464.1
Location: 2401034..2401264 (231 bp)
Type: Others
Protein ID: WP_009988466.1
Location: 2401739..2402170 (432 bp)
Type: Others
Protein ID: WP_009988468.1
Location: 2403829..2404761 (933 bp)
Type: Others
Protein ID: WP_009988516.1
Location: 2404706..2405902 (1197 bp)
Type: Others
Protein ID: WP_009988517.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULI_RS13345 (SULI_13380)2396001..2396600-600WP_009991466.1DUF2249 domain-containing protein-
SULI_RS13350 (SULI_13385)2397327..2397569+243WP_009988456.1hypothetical protein-
SULI_RS13355 (SULI_13390)2397550..2397894-345WP_009988458.1hypothetical protein-
SULI_RS13360 (SULI_13395)2397898..2398662-765WP_009988459.1plastocyanin/azurin family copper-binding protein-
SULI_RS13365 (SULI_13400)2398768..2399298-531WP_009988460.1hemerythrin domain-containing protein-
SULI_RS13370 (SULI_13405)2399420..2399695+276WP_009988461.1hypothetical protein-
SULI_RS13375 (SULI_13410)2399985..2400599-615WP_009988462.1helix-turn-helix domain-containing proteinToxin
SULI_RS13380 (SULI_13415)2400617..2400964-348WP_009988464.1DUF488 domain-containing proteinAntitoxin
SULI_RS13385 (SULI_13420)2401034..2401264-231WP_009988466.1C2H2-type zinc finger protein-
SULI_RS13390 (SULI_13425)2401357..2401746+390WP_009988467.1metal-sulfur cluster assembly factor-
SULI_RS13395 (SULI_13430)2401739..2402170-432WP_009988468.1universal stress protein-
SULI_RS13400 (SULI_13435)2402433..2403392+960WP_010923364.1IS5-like element ISC1234 family transposase-
SULI_RS13405 (SULI_13440)2403829..2404761-933WP_009988516.1dipeptidase-
SULI_RS13410 (SULI_13445)2404706..2405902-1197WP_009988517.1MFS transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--2402433..2403392959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T113445 WP_009988462.1 NZ_CP033237:c2400599-2399985 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T113445 NZ_CP033237:c2400599-2399985 [Saccharolobus solfataricus]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT113445 WP_009988464.1 NZ_CP033237:c2400964-2400617 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT113445 NZ_CP033237:c2400964-2400617 [Saccharolobus solfataricus]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3MDP8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3GU05

References