Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2538736..2539342 | Replicon | chromosome |
| Accession | NZ_CP033236 | ||
| Organism | Saccharolobus solfataricus strain SARC-H | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q97WY9 |
| Locus tag | SULH_RS14215 | Protein ID | WP_009991922.1 |
| Coordinates | 2538950..2539342 (+) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | C3NC15 |
| Locus tag | SULH_RS14210 | Protein ID | WP_009991920.1 |
| Coordinates | 2538736..2538960 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SULH_RS14175 (SULH_14215) | 2533971..2534921 | - | 951 | WP_010923701.1 | IS110 family transposase | - |
| SULH_RS14180 (SULH_14220) | 2535080..2535364 | + | 285 | Protein_2752 | IS607-like element ISC1913 family transposase | - |
| SULH_RS14185 (SULH_14225) | 2535348..2536568 | + | 1221 | WP_014511730.1 | IS200/IS605 family accessory protein TnpB-related protein | - |
| SULH_RS14190 (SULH_14230) | 2536716..2537102 | - | 387 | WP_009991912.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULH_RS14195 (SULH_14235) | 2537089..2537364 | - | 276 | WP_009991915.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SULH_RS14200 (SULH_14240) | 2537735..2537971 | + | 237 | WP_009991916.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SULH_RS14205 (SULH_14245) | 2537949..2538347 | + | 399 | WP_009991918.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULH_RS14210 (SULH_14250) | 2538736..2538960 | + | 225 | WP_009991920.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| SULH_RS14215 (SULH_14255) | 2538950..2539342 | + | 393 | WP_009991922.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SULH_RS14220 (SULH_14260) | 2539516..2540466 | + | 951 | WP_010923701.1 | IS110 family transposase | - |
| SULH_RS14225 (SULH_14265) | 2540540..2541589 | - | 1050 | Protein_2761 | AMP-binding protein | - |
| SULH_RS14230 (SULH_14270) | 2541690..2542805 | + | 1116 | WP_009988843.1 | acyl-CoA dehydrogenase family protein | - |
| SULH_RS14235 (SULH_14275) | 2542868..2544013 | + | 1146 | WP_009988841.1 | thiolase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 2533539..2540466 | 6927 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 15105.86 Da Isoelectric Point: 8.2957
>T113440 WP_009991922.1 NZ_CP033236:2538950-2539342 [Saccharolobus solfataricus]
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
Download Length: 393 bp
>T113440 NZ_CP033236:2538950-2539342 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8881.24 Da Isoelectric Point: 5.0355
>AT113440 WP_009991920.1 NZ_CP033236:2538736-2538960 [Saccharolobus solfataricus]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
Download Length: 225 bp
>AT113440 NZ_CP033236:2538736-2538960 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3K6Y2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3MHL6 |