Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 2536716..2537364 Replicon chromosome
Accession NZ_CP033236
Organism Saccharolobus solfataricus strain SARC-H

Toxin (Protein)


Gene name vapC Uniprot ID Q97WZ2
Locus tag SULH_RS14190 Protein ID WP_009991912.1
Coordinates 2536716..2537102 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97WZ1
Locus tag SULH_RS14195 Protein ID WP_009991915.1
Coordinates 2537089..2537364 (-) Length 92 a.a.

Genomic Context

SULH_RS14170SULH_RS14180SULH_RS14185SULH_RS14200SULH_RS14205SULH_RS14210SULH_RS14215SULH_RS14220SULH_RS14160SULH_RS14165SULH_RS14175SULH_RS14190SULH_RS14195SULH_RS14225
Location: 2533539..2533895 (357 bp)
Type: Others
Protein ID: Protein_2750
Location: 2535080..2535364 (285 bp)
Type: Others
Protein ID: Protein_2752
Location: 2535348..2536568 (1221 bp)
Type: Others
Protein ID: WP_014511730.1
Location: 2537735..2537971 (237 bp)
Type: Others
Protein ID: WP_009991916.1
Location: 2537949..2538347 (399 bp)
Type: Others
Protein ID: WP_009991918.1
Location: 2538736..2538960 (225 bp)
Type: Others
Protein ID: WP_009991920.1
Location: 2538950..2539342 (393 bp)
Type: Others
Protein ID: WP_009991922.1
Location: 2539516..2540466 (951 bp)
Type: Others
Protein ID: WP_010923701.1
Location: 2531798..2532571 (774 bp)
Type: Others
Protein ID: WP_009991748.1
Location: 2532827..2533252 (426 bp)
Type: Others
Protein ID: WP_009991747.1
Location: 2533971..2534921 (951 bp)
Type: Others
Protein ID: WP_010923701.1
Location: 2536716..2537102 (387 bp)
Type: Toxin
Protein ID: WP_009991912.1
Location: 2537089..2537364 (276 bp)
Type: Antitoxin
Protein ID: WP_009991915.1
Location: 2540540..2541589 (1050 bp)
Type: Others
Protein ID: Protein_2761
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULH_RS14160 (SULH_14200)2531798..2532571-774WP_009991748.1extradiol dioxygenase-
SULH_RS14165 (SULH_14205)2532827..2533252-426WP_009991747.1DUF4143 domain-containing protein-
SULH_RS14170 (SULH_14210)2533539..2533895+357Protein_2750IS607 family transposase-
SULH_RS14175 (SULH_14215)2533971..2534921-951WP_010923701.1IS110 family transposase-
SULH_RS14180 (SULH_14220)2535080..2535364+285Protein_2752IS607-like element ISC1913 family transposase-
SULH_RS14185 (SULH_14225)2535348..2536568+1221WP_014511730.1IS200/IS605 family accessory protein TnpB-related protein-
SULH_RS14190 (SULH_14230)2536716..2537102-387WP_009991912.1type II toxin-antitoxin system VapC family toxinToxin
SULH_RS14195 (SULH_14235)2537089..2537364-276WP_009991915.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SULH_RS14200 (SULH_14240)2537735..2537971+237WP_009991916.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
SULH_RS14205 (SULH_14245)2537949..2538347+399WP_009991918.1type II toxin-antitoxin system VapC family toxin-
SULH_RS14210 (SULH_14250)2538736..2538960+225WP_009991920.1type II toxin-antitoxin system CcdA family antitoxin-
SULH_RS14215 (SULH_14255)2538950..2539342+393WP_009991922.1type II toxin-antitoxin system VapC family toxin-
SULH_RS14220 (SULH_14260)2539516..2540466+951WP_010923701.1IS110 family transposase-
SULH_RS14225 (SULH_14265)2540540..2541589-1050Protein_2761AMP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIScluster/Tn--2533539..25404666927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 15042.69 Da        Isoelectric Point: 4.9844

>T113439 WP_009991912.1 NZ_CP033236:c2537102-2536716 [Saccharolobus solfataricus]
MIFLDANFLIYLNSGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVKPSDAFHIAVMLNNSINVILSEDKELDKVAEIKRIWI

Download         Length: 387 bp

>T113439 NZ_CP033236:c2537102-2536716 [Saccharolobus solfataricus]
TTGATTTTTCTTGATGCTAATTTCTTAATCTACTTAAACTCGGGTGTAAGTGAGGTAAAAGAGTATTATATAAAACTCCT
CACATATGAAAGCTTGTTTTCAGATCCTTTAGTTATAGATGAGGTAATATACGTGTCTAAGAAGAAGTATGGAGTTAAGT
ATTGCGATACCATAGAATTCTTGGATGAAATAGTGCTCAAGTACTTAACAGTTTTACCAATCACGATAAAGGAATATGAG
AGGGCTAAAGAAATTATGAGAAAATACTCAGTTAAGCCATCTGATGCCTTTCATATTGCCGTAATGTTAAACAATTCAAT
AAACGTGATCTTAAGTGAAGATAAGGAGTTAGATAAAGTTGCAGAAATAAAGAGAATATGGATTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10372.22 Da        Isoelectric Point: 7.0185

>AT113439 WP_009991915.1 NZ_CP033236:c2537364-2537089 [Saccharolobus solfataricus]
MSLTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENI
SLEEELKIDFS

Download         Length: 276 bp

>AT113439 NZ_CP033236:c2537364-2537089 [Saccharolobus solfataricus]
ATGAGTTTGACTCTAAGAGTGGAAGTTGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAAT
AAAAGAGGGGGATATCTTAATTTTGACAGTCGTTGGAGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAG
AAGTTGTCAAAAAATTAGAAGAACATGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATA
AGTCTTGAAGAGGAATTGAAGATTGATTTTTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3KDP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3MDU1

References