113438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2399985..2400964 Replicon chromosome
Accession NZ_CP033236
Organism Saccharolobus solfataricus strain SARC-H

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SULH_RS13375 Protein ID WP_009988462.1
Coordinates 2399985..2400599 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SULH_RS13380 Protein ID WP_009988464.1
Coordinates 2400617..2400964 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULH_RS13345 (SULH_13380) 2396001..2396600 - 600 WP_009991466.1 DUF2249 domain-containing protein -
SULH_RS13350 (SULH_13385) 2397327..2397569 + 243 WP_009988456.1 hypothetical protein -
SULH_RS13355 (SULH_13390) 2397550..2397894 - 345 WP_009988458.1 hypothetical protein -
SULH_RS13360 (SULH_13395) 2397898..2398662 - 765 WP_009988459.1 plastocyanin/azurin family copper-binding protein -
SULH_RS13365 (SULH_13400) 2398768..2399298 - 531 WP_009988460.1 hemerythrin domain-containing protein -
SULH_RS13370 (SULH_13405) 2399420..2399695 + 276 WP_009988461.1 hypothetical protein -
SULH_RS13375 (SULH_13410) 2399985..2400599 - 615 WP_009988462.1 helix-turn-helix domain-containing protein Toxin
SULH_RS13380 (SULH_13415) 2400617..2400964 - 348 WP_009988464.1 DUF488 domain-containing protein Antitoxin
SULH_RS13385 (SULH_13420) 2401034..2401264 - 231 WP_009988466.1 C2H2-type zinc finger protein -
SULH_RS13390 (SULH_13425) 2401357..2401746 + 390 WP_009988467.1 metal-sulfur cluster assembly factor -
SULH_RS13395 (SULH_13430) 2401739..2402170 - 432 WP_009988468.1 universal stress protein -
SULH_RS13400 (SULH_13435) 2402433..2403392 + 960 WP_010923364.1 IS5-like element ISC1234 family transposase -
SULH_RS13405 (SULH_13440) 2403829..2404761 - 933 WP_009988516.1 dipeptidase -
SULH_RS13410 (SULH_13445) 2404706..2405902 - 1197 WP_009988517.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2402433..2403392 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T113438 WP_009988462.1 NZ_CP033236:c2400599-2399985 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T113438 NZ_CP033236:c2400599-2399985 [Saccharolobus solfataricus]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT113438 WP_009988464.1 NZ_CP033236:c2400964-2400617 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT113438 NZ_CP033236:c2400964-2400617 [Saccharolobus solfataricus]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3MDP8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3GU05

References