Detailed information of TA system TA113437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 2345634..2346281
• Replicon: chromosome
• Accession: NZ_CP033236
• Organism: Saccharolobus solfataricus strain SARC-H

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SULH_RS13035
• Protein ID: WP_009990357.1
• Coordinates: 2345634..2345906 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0E3K976
• Locus tag: SULH_RS13040
• Protein ID: WP_009990356.1
• Coordinates: 2346021..2346281 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULH_RS13010 (SULH_13040)	2340949..2342000	-	1052	Protein_2523	ISH3-like element ISC1359 family transposase	-
SULH_RS13015 (SULH_13045)	2342104..2342853	+	750	Protein_2524	GDP-mannose 4,6-dehydratase	-
SULH_RS13025 (SULH_13060)	2344164..2345111	-	948	WP_009990359.1	ATP/GTP-binding protein	-
SULH_RS13035 (SULH_13070)	2345634..2345906	-	273	WP_009990357.1	PIN domain-containing protein	Toxin
SULH_RS13040 (SULH_13075)	2346021..2346281	-	261	WP_009990356.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SULH_RS13045 (SULH_13080)	2346968..2347129	+	162	WP_009990355.1	hypothetical protein	-
SULH_RS13050 (SULH_13085)	2347231..2347689	+	459	WP_009990354.1	hypothetical protein	-
SULH_RS13055 (SULH_13090)	2348438..2348944	-	507	WP_014511696.1	thiosulfate:quinone oxidoreductase small subunit	-
SULH_RS13060 (SULH_13095)	2348950..2349492	-	543	WP_009990352.1	thiosulfate:quinone oxidoreductase large subunit	-
SULH_RS13065 (SULH_13100)	2349800..2350675	-	876	Protein_2532	transposase	-
SULH_RS13070 (SULH_13105)	2351036..2351269	+	234	WP_009993269.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (20-82)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10475.34 Da
• Isoelectric Point: 9.7534

>T113437 WP_009990357.1 NZ_CP033236:c2345906-2345634 [Saccharolobus solfataricus]
MRLFTLSKKKYNVKFEDTIDFLDKIILPYTIILPINSHDYEKAKGIMISKTLKPSDAFHVAVMINNSIKKIVSEDSDFDK
INGIERIWVK

Nucleotide

• Length: 273 bp

>T113437 NZ_CP033236:c2345906-2345634 [Saccharolobus solfataricus]
ATGAGGTTATTTACATTATCAAAAAAGAAGTATAATGTAAAATTTGAGGATACAATTGATTTCTTAGATAAGATAATACT
TCCTTATACAATTATACTGCCAATCAACTCTCATGATTATGAAAAAGCAAAGGGGATAATGATAAGTAAGACTTTAAAAC
CGTCTGATGCTTTCCACGTAGCTGTAATGATAAATAATTCAATAAAAAAGATAGTAAGTGAGGATTCAGATTTCGATAAA
ATTAATGGAATAGAAAGGATTTGGGTAAAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9842.51 Da
• Isoelectric Point: 5.2456

>AT113437 WP_009990356.1 NZ_CP033236:c2346281-2346021 [Saccharolobus solfataricus]
MTLKIEVGKKGYIIIPKTVRDLLEIKEGDILILRVEDGKIVLEPERKVSFDDLKKKMEEHSAKISYANKAKLGDLINVSL
EEEFDN

Nucleotide

• Length: 261 bp

>AT113437 NZ_CP033236:c2346281-2346021 [Saccharolobus solfataricus]
TTGACCCTAAAGATTGAAGTTGGAAAGAAAGGATATATAATAATCCCTAAGACTGTTAGGGATCTTCTTGAAATAAAGGA
GGGAGATATATTAATCCTAAGAGTCGAAGATGGTAAAATTGTTCTTGAGCCTGAAAGAAAGGTAAGTTTTGATGACTTAA
AAAAGAAGATGGAGGAACATAGTGCTAAAATCTCATATGCAAATAAGGCTAAACTTGGAGATTTAATTAACGTTAGTTTA
GAGGAGGAATTCGATAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E3K976