Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 2345634..2346281 Replicon chromosome
Accession NZ_CP033236
Organism Saccharolobus solfataricus strain SARC-H

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SULH_RS13035 Protein ID WP_009990357.1
Coordinates 2345634..2345906 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E3K976
Locus tag SULH_RS13040 Protein ID WP_009990356.1
Coordinates 2346021..2346281 (-) Length 87 a.a.

Genomic Context

SULH_RS13015SULH_RS13045SULH_RS13050SULH_RS13070SULH_RS13010SULH_RS13025SULH_RS13035SULH_RS13040SULH_RS13055SULH_RS13060SULH_RS13065
Location: 2342104..2342853 (750 bp)
Type: Others
Protein ID: Protein_2524
Location: 2346968..2347129 (162 bp)
Type: Others
Protein ID: WP_009990355.1
Location: 2347231..2347689 (459 bp)
Type: Others
Protein ID: WP_009990354.1
Location: 2351036..2351269 (234 bp)
Type: Others
Protein ID: WP_009993269.1
Location: 2340949..2342000 (1052 bp)
Type: Others
Protein ID: Protein_2523
Location: 2344164..2345111 (948 bp)
Type: Others
Protein ID: WP_009990359.1
Location: 2345634..2345906 (273 bp)
Type: Toxin
Protein ID: WP_009990357.1
Location: 2346021..2346281 (261 bp)
Type: Antitoxin
Protein ID: WP_009990356.1
Location: 2348438..2348944 (507 bp)
Type: Others
Protein ID: WP_014511696.1
Location: 2348950..2349492 (543 bp)
Type: Others
Protein ID: WP_009990352.1
Location: 2349800..2350675 (876 bp)
Type: Others
Protein ID: Protein_2532
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULH_RS13010 (SULH_13040)2340949..2342000-1052Protein_2523ISH3-like element ISC1359 family transposase-
SULH_RS13015 (SULH_13045)2342104..2342853+750Protein_2524GDP-mannose 4,6-dehydratase-
SULH_RS13025 (SULH_13060)2344164..2345111-948WP_009990359.1ATP/GTP-binding protein-
SULH_RS13035 (SULH_13070)2345634..2345906-273WP_009990357.1PIN domain-containing proteinToxin
SULH_RS13040 (SULH_13075)2346021..2346281-261WP_009990356.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SULH_RS13045 (SULH_13080)2346968..2347129+162WP_009990355.1hypothetical protein-
SULH_RS13050 (SULH_13085)2347231..2347689+459WP_009990354.1hypothetical protein-
SULH_RS13055 (SULH_13090)2348438..2348944-507WP_014511696.1thiosulfate:quinone oxidoreductase small subunit-
SULH_RS13060 (SULH_13095)2348950..2349492-543WP_009990352.1thiosulfate:quinone oxidoreductase large subunit-
SULH_RS13065 (SULH_13100)2349800..2350675-876Protein_2532transposase-
SULH_RS13070 (SULH_13105)2351036..2351269+234WP_009993269.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(20-82)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10475.34 Da        Isoelectric Point: 9.7534

>T113437 WP_009990357.1 NZ_CP033236:c2345906-2345634 [Saccharolobus solfataricus]
MRLFTLSKKKYNVKFEDTIDFLDKIILPYTIILPINSHDYEKAKGIMISKTLKPSDAFHVAVMINNSIKKIVSEDSDFDK
INGIERIWVK

Download         Length: 273 bp

>T113437 NZ_CP033236:c2345906-2345634 [Saccharolobus solfataricus]
ATGAGGTTATTTACATTATCAAAAAAGAAGTATAATGTAAAATTTGAGGATACAATTGATTTCTTAGATAAGATAATACT
TCCTTATACAATTATACTGCCAATCAACTCTCATGATTATGAAAAAGCAAAGGGGATAATGATAAGTAAGACTTTAAAAC
CGTCTGATGCTTTCCACGTAGCTGTAATGATAAATAATTCAATAAAAAAGATAGTAAGTGAGGATTCAGATTTCGATAAA
ATTAATGGAATAGAAAGGATTTGGGTAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9842.51 Da        Isoelectric Point: 5.2456

>AT113437 WP_009990356.1 NZ_CP033236:c2346281-2346021 [Saccharolobus solfataricus]
MTLKIEVGKKGYIIIPKTVRDLLEIKEGDILILRVEDGKIVLEPERKVSFDDLKKKMEEHSAKISYANKAKLGDLINVSL
EEEFDN

Download         Length: 261 bp

>AT113437 NZ_CP033236:c2346281-2346021 [Saccharolobus solfataricus]
TTGACCCTAAAGATTGAAGTTGGAAAGAAAGGATATATAATAATCCCTAAGACTGTTAGGGATCTTCTTGAAATAAAGGA
GGGAGATATATTAATCCTAAGAGTCGAAGATGGTAAAATTGTTCTTGAGCCTGAAAGAAAGGTAAGTTTTGATGACTTAA
AAAAGAAGATGGAGGAACATAGTGCTAAAATCTCATATGCAAATAAGGCTAAACTTGGAGATTTAATTAACGTTAGTTTA
GAGGAGGAATTCGATAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3K976

References