Detailed information of TA system TA113436

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2139201..2139888
• Replicon: chromosome
• Accession: NZ_CP033236
• Organism: Saccharolobus solfataricus strain SARC-H

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SULH_RS11965
• Protein ID: WP_231918326.1
• Coordinates: 2139553..2139888 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SULH_RS11960
• Protein ID: WP_009991659.1
• Coordinates: 2139201..2139503 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULH_RS11940 (SULH_11950)	2135125..2135668	-	544	Protein_2311	IS607 family transposase	-
SULH_RS11945 (SULH_11955)	2135996..2136663	+	668	Protein_2312	ISNCY family transposase	-
SULH_RS11950 (SULH_11960)	2137072..2137644	-	573	WP_010923431.1	metallophosphoesterase	-
SULH_RS11955 (SULH_11965)	2137660..2138672	-	1013	Protein_2314	IS630-like element ISC1078 family transposase	-
SULH_RS11960 (SULH_11970)	2139201..2139503	+	303	WP_009991659.1	hypothetical protein	Antitoxin
SULH_RS11965 (SULH_11975)	2139553..2139888	+	336	WP_231918326.1	type II toxin-antitoxin system VapC family toxin	Toxin
SULH_RS11970 (SULH_11980)	2140096..2141211	+	1116	WP_009991657.1	hypothetical protein	-
SULH_RS11975 (SULH_11985)	2141355..2141690	-	336	Protein_2318	transposase	-
SULH_RS11980 (SULH_11990)	2141872..2142017	-	146	Protein_2319	IS630 family transposase	-
SULH_RS15360	2141962..2142153	+	192	WP_048056702.1	hypothetical protein	-
SULH_RS11990 (SULH_12000)	2142413..2142910	-	498	WP_014511660.1	hypothetical protein	-
SULH_RS11995 (SULH_12005)	2143052..2144025	-	974	Protein_2322	IS5 family transposase	-
SULH_RS12000 (SULH_12010)	2144150..2144488	+	339	WP_010923427.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2098409..2311978	213569
	-	inside	IScluster/Tn	-	-	2133891..2147667	13776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-104)

Antitoxin

• Putative antitoxin VapB3-like (28-100)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12427.61 Da
• Isoelectric Point: 5.2389

>T113436 WP_231918326.1 NZ_CP033236:2139553-2139888 [Saccharolobus solfataricus]
IREILKDAETLDFALVEVSNVVWKKAVLTGELTGKDVIKAITIVKEYLPQLLTVNKSIDLIERAIEISVNEKITVYDSLY
IALAECKGSKLVTGDKKQYDVAKKYVISELI

Nucleotide

• Length: 336 bp

>T113436 NZ_CP033236:2139553-2139888 [Saccharolobus solfataricus]
ATTAGAGAGATTTTGAAAGACGCTGAGACATTAGACTTCGCATTAGTGGAAGTATCTAACGTAGTATGGAAGAAAGCTGT
ATTAACTGGGGAATTAACTGGGAAAGATGTAATTAAGGCAATTACTATTGTTAAAGAGTATTTACCACAACTGCTTACAG
TTAACAAAAGCATTGACTTAATTGAAAGAGCTATTGAGATTTCCGTTAACGAGAAAATCACAGTATATGATTCACTTTAT
ATTGCACTGGCTGAATGTAAGGGGAGTAAATTGGTAACGGGGGATAAGAAACAATACGACGTAGCTAAAAAGTACGTCAT
CTCTGAGCTCATATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12195.09 Da
• Isoelectric Point: 4.8275

>AT113436 WP_009991659.1 NZ_CP033236:2139201-2139503 [Saccharolobus solfataricus]
MVIKNATILIYVPEIETFIFPVYVYYNMKTVYSLRLDKELREEMEKYNVKWNEEIESFIRKRIEELKKEEILKKINEILQ
TMPETKSNSADLVREDRDNN

Nucleotide

• Length: 303 bp

>AT113436 NZ_CP033236:2139201-2139503 [Saccharolobus solfataricus]
ATGGTAATAAAGAATGCTACAATTTTAATCTATGTACCAGAGATAGAAACGTTTATATTTCCCGTATACGTGTATTATAA
TATGAAAACCGTATACAGTTTAAGGTTAGATAAGGAATTACGTGAGGAGATGGAGAAATATAACGTCAAGTGGAATGAGG
AGATAGAGAGCTTTATAAGAAAGAGAATTGAGGAATTGAAGAAAGAGGAGATCTTAAAGAAGATTAATGAAATCCTCCAA
ACAATGCCAGAAACTAAGTCAAATAGTGCAGATTTGGTGAGGGAAGATAGGGATAATAATTGA