Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 767074..767680 Replicon chromosome
Accession NZ_CP033236
Organism Saccharolobus solfataricus strain SARC-H

Toxin (Protein)


Gene name vapC Uniprot ID Q97UE3
Locus tag SULH_RS04160 Protein ID WP_009989090.1
Coordinates 767074..767478 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9UBQ9
Locus tag SULH_RS04165 Protein ID WP_009989091.1
Coordinates 767459..767680 (-) Length 74 a.a.

Genomic Context

SULH_RS04140SULH_RS04145SULH_RS04155SULH_RS04170SULH_RS04175SULH_RS04180SULH_RS04185SULH_RS04125SULH_RS04130SULH_RS04150SULH_RS04160SULH_RS04165SULH_RS04190SULH_RS04195
Location: 764503..765282 (780 bp)
Type: Others
Protein ID: WP_014511459.1
Location: 765720..766444 (725 bp)
Type: Others
Protein ID: Protein_815
Location: 766591..766878 (288 bp)
Type: Others
Protein ID: WP_272898411.1
Location: 768209..768409 (201 bp)
Type: Others
Protein ID: WP_009989095.1
Location: 768463..768693 (231 bp)
Type: Others
Protein ID: WP_009989096.1
Location: 768804..770075 (1272 bp)
Type: Others
Protein ID: WP_009989097.1
Location: 770194..770859 (666 bp)
Type: Others
Protein ID: WP_009989098.1
Location: 762576..763337 (762 bp)
Type: Others
Protein ID: WP_009990867.1
Location: 763485..763667 (183 bp)
Type: Others
Protein ID: WP_009990866.1
Location: 766442..766549 (108 bp)
Type: Others
Protein ID: Protein_816
Location: 767074..767478 (405 bp)
Type: Toxin
Protein ID: WP_009989090.1
Location: 767459..767680 (222 bp)
Type: Antitoxin
Protein ID: WP_009989091.1
Location: 770856..771242 (387 bp)
Type: Others
Protein ID: WP_009989099.1
Location: 771239..771856 (618 bp)
Type: Others
Protein ID: WP_009989100.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULH_RS04125 (SULH_04130)762576..763337-762WP_009990867.1ZIP family metal transporter-
SULH_RS04130 (SULH_04135)763485..763667-183WP_009990866.1hypothetical protein-
SULH_RS04140 (SULH_04145)764503..765282+780WP_014511459.1DMT family transporter-
SULH_RS04145 (SULH_04150)765720..766444+725Protein_815transposase-
SULH_RS04150 (SULH_04155)766442..766549-108Protein_816IS110 family transposase-
SULH_RS04155 (SULH_04160)766591..766878+288WP_272898411.1transposase-
SULH_RS04160 (SULH_04165)767074..767478-405WP_009989090.1PIN domain-containing proteinToxin
SULH_RS04165 (SULH_04170)767459..767680-222WP_009989091.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SULH_RS04170 (SULH_04175)768209..768409+201WP_009989095.1hypothetical protein-
SULH_RS04175 (SULH_04180)768463..768693+231WP_009989096.1EamA family transporter-
SULH_RS04180 (SULH_04185)768804..770075+1272WP_009989097.1MFS transporter-
SULH_RS04185 (SULH_04190)770194..770859+666WP_009989098.1helix-turn-helix domain-containing protein-
SULH_RS04190 (SULH_04195)770856..771242-387WP_009989099.1hypothetical protein-
SULH_RS04195 (SULH_04200)771239..771856-618WP_009989100.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15426.98 Da        Isoelectric Point: 5.0272

>T113434 WP_009989090.1 NZ_CP033236:c767478-767074 [Saccharolobus solfataricus]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLNKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS

Download         Length: 405 bp

>T113434 NZ_CP033236:c767478-767074 [Saccharolobus solfataricus]
GTGGAGAAGGCAATAGTTGACACTAACGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCGGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTGGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATATTAGAAGTGAGAAAGCTGAGGTTGTCTGCGATTGTACAGATAACGTC
ACTGACGCTATAGGAGTGCTGAATAAGGAAAAGCTTCCCTTGGTCAGCTACAAAGATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGAAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTGCTACAGT
CGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8267.50 Da        Isoelectric Point: 9.6908

>AT113434 WP_009989091.1 NZ_CP033236:c767680-767459 [Saccharolobus solfataricus]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS

Download         Length: 222 bp

>AT113434 NZ_CP033236:c767680-767459 [Saccharolobus solfataricus]
ATGGAGAGGGTAAAGGTTACGAGAAATTACCAGATAACTATTCCAGCCTCGGCTAGGAGTAAGATTAATATAAAAGAAGG
AGATATACTTGAGGTTTACTTGAACGGTGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAG
GCAGTAAACTCTCACTGGGAGATATTGAGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3K068

Antitoxin

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Source
ID
Structure
AlphaFold DBM9UBQ9

References