113434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 767074..767680 Replicon chromosome
Accession NZ_CP033236
Organism Saccharolobus solfataricus strain SARC-H

Toxin (Protein)


Gene name vapC Uniprot ID Q97UE3
Locus tag SULH_RS04160 Protein ID WP_009989090.1
Coordinates 767074..767478 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9UBQ9
Locus tag SULH_RS04165 Protein ID WP_009989091.1
Coordinates 767459..767680 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULH_RS04125 (SULH_04130) 762576..763337 - 762 WP_009990867.1 ZIP family metal transporter -
SULH_RS04130 (SULH_04135) 763485..763667 - 183 WP_009990866.1 hypothetical protein -
SULH_RS04140 (SULH_04145) 764503..765282 + 780 WP_014511459.1 DMT family transporter -
SULH_RS04145 (SULH_04150) 765720..766444 + 725 Protein_815 transposase -
SULH_RS04150 (SULH_04155) 766442..766549 - 108 Protein_816 IS110 family transposase -
SULH_RS04155 (SULH_04160) 766591..766878 + 288 WP_272898411.1 transposase -
SULH_RS04160 (SULH_04165) 767074..767478 - 405 WP_009989090.1 PIN domain-containing protein Toxin
SULH_RS04165 (SULH_04170) 767459..767680 - 222 WP_009989091.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SULH_RS04170 (SULH_04175) 768209..768409 + 201 WP_009989095.1 hypothetical protein -
SULH_RS04175 (SULH_04180) 768463..768693 + 231 WP_009989096.1 EamA family transporter -
SULH_RS04180 (SULH_04185) 768804..770075 + 1272 WP_009989097.1 MFS transporter -
SULH_RS04185 (SULH_04190) 770194..770859 + 666 WP_009989098.1 helix-turn-helix domain-containing protein -
SULH_RS04190 (SULH_04195) 770856..771242 - 387 WP_009989099.1 hypothetical protein -
SULH_RS04195 (SULH_04200) 771239..771856 - 618 WP_009989100.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15426.98 Da        Isoelectric Point: 5.0272

>T113434 WP_009989090.1 NZ_CP033236:c767478-767074 [Saccharolobus solfataricus]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLNKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS

Download         Length: 405 bp

>T113434 NZ_CP033236:c767478-767074 [Saccharolobus solfataricus]
GTGGAGAAGGCAATAGTTGACACTAACGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCGGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTGGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATATTAGAAGTGAGAAAGCTGAGGTTGTCTGCGATTGTACAGATAACGTC
ACTGACGCTATAGGAGTGCTGAATAAGGAAAAGCTTCCCTTGGTCAGCTACAAAGATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGAAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTGCTACAGT
CGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8267.50 Da        Isoelectric Point: 9.6908

>AT113434 WP_009989091.1 NZ_CP033236:c767680-767459 [Saccharolobus solfataricus]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS

Download         Length: 222 bp

>AT113434 NZ_CP033236:c767680-767459 [Saccharolobus solfataricus]
ATGGAGAGGGTAAAGGTTACGAGAAATTACCAGATAACTATTCCAGCCTCGGCTAGGAGTAAGATTAATATAAAAGAAGG
AGATATACTTGAGGTTTACTTGAACGGTGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAG
GCAGTAAACTCTCACTGGGAGATATTGAGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3K068

Antitoxin

Source ID Structure
AlphaFold DB M9UBQ9

References