Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2538736..2539342 Replicon chromosome
Accession NZ_CP033235
Organism Saccharolobus solfataricus strain SULG

Toxin (Protein)


Gene name vapC Uniprot ID Q97WY9
Locus tag SULG_RS14215 Protein ID WP_009991922.1
Coordinates 2538950..2539342 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C3NC15
Locus tag SULG_RS14210 Protein ID WP_009991920.1
Coordinates 2538736..2538960 (+) Length 75 a.a.

Genomic Context

SULG_RS14180SULG_RS14185SULG_RS14200SULG_RS14205SULG_RS14210SULG_RS14215SULG_RS14220SULG_RS14230SULG_RS14235SULG_RS14175SULG_RS14190SULG_RS14195SULG_RS14225
Location: 2535080..2535364 (285 bp)
Type: Others
Protein ID: Protein_2752
Location: 2535348..2536568 (1221 bp)
Type: Others
Protein ID: WP_014511730.1
Location: 2537735..2537971 (237 bp)
Type: Others
Protein ID: WP_009991916.1
Location: 2537949..2538347 (399 bp)
Type: Others
Protein ID: WP_009991918.1
Location: 2538736..2538960 (225 bp)
Type: Antitoxin
Protein ID: WP_009991920.1
Location: 2538950..2539342 (393 bp)
Type: Toxin
Protein ID: WP_009991922.1
Location: 2539516..2540466 (951 bp)
Type: Others
Protein ID: WP_010923701.1
Location: 2541690..2542805 (1116 bp)
Type: Others
Protein ID: WP_009988843.1
Location: 2542868..2544013 (1146 bp)
Type: Others
Protein ID: WP_009988841.1
Location: 2533971..2534921 (951 bp)
Type: Others
Protein ID: WP_010923701.1
Location: 2536716..2537102 (387 bp)
Type: Others
Protein ID: WP_009991912.1
Location: 2537089..2537364 (276 bp)
Type: Others
Protein ID: WP_009991915.1
Location: 2540540..2541589 (1050 bp)
Type: Others
Protein ID: Protein_2761
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULG_RS14175 (SULG_14215)2533971..2534921-951WP_010923701.1IS110 family transposase-
SULG_RS14180 (SULG_14220)2535080..2535364+285Protein_2752IS607-like element ISC1913 family transposase-
SULG_RS14185 (SULG_14225)2535348..2536568+1221WP_014511730.1IS200/IS605 family accessory protein TnpB-related protein-
SULG_RS14190 (SULG_14230)2536716..2537102-387WP_009991912.1type II toxin-antitoxin system VapC family toxin-
SULG_RS14195 (SULG_14235)2537089..2537364-276WP_009991915.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
SULG_RS14200 (SULG_14240)2537735..2537971+237WP_009991916.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
SULG_RS14205 (SULG_14245)2537949..2538347+399WP_009991918.1type II toxin-antitoxin system VapC family toxin-
SULG_RS14210 (SULG_14250)2538736..2538960+225WP_009991920.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
SULG_RS14215 (SULG_14255)2538950..2539342+393WP_009991922.1type II toxin-antitoxin system VapC family toxinToxin
SULG_RS14220 (SULG_14260)2539516..2540466+951WP_010923701.1IS110 family transposase-
SULG_RS14225 (SULG_14265)2540540..2541589-1050Protein_2761AMP-binding protein-
SULG_RS14230 (SULG_14270)2541690..2542805+1116WP_009988843.1acyl-CoA dehydrogenase family protein-
SULG_RS14235 (SULG_14275)2542868..2544013+1146WP_009988841.1thiolase domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIScluster/Tn--2533539..25404666927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(23-118)

Antitoxin

Post-segregation antitoxin CcdA

(5-44)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15105.86 Da        Isoelectric Point: 8.2957

>T113433 WP_009991922.1 NZ_CP033235:2538950-2539342 [Saccharolobus solfataricus]
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T113433 NZ_CP033235:2538950-2539342 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8881.24 Da        Isoelectric Point: 5.0355

>AT113433 WP_009991920.1 NZ_CP033235:2538736-2538960 [Saccharolobus solfataricus]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER

Download         Length: 225 bp

>AT113433 NZ_CP033235:2538736-2538960 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3K6Y2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3MHL6

References