Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1985646..1986252 Replicon chromosome
Accession NZ_CP033235
Organism Saccharolobus solfataricus strain SULG

Toxin (Protein)


Gene name vapC Uniprot ID Q97YS3
Locus tag SULG_RS11305 Protein ID WP_009993017.1
Coordinates 1985860..1986252 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E3MAZ1
Locus tag SULG_RS11300 Protein ID WP_014511634.1
Coordinates 1985646..1985870 (+) Length 75 a.a.

Genomic Context

SULG_RS11275SULG_RS11280SULG_RS11290SULG_RS11295SULG_RS11300SULG_RS11305SULG_RS11315SULG_RS11285SULG_RS11310SULG_RS11320SULG_RS11325SULG_RS11330
Location: 1980794..1981924 (1131 bp)
Type: Others
Protein ID: WP_009992604.1
Location: 1981921..1982382 (462 bp)
Type: Others
Protein ID: WP_010923265.1
Location: 1983385..1984368 (984 bp)
Type: Others
Protein ID: WP_010923242.1
Location: 1984367..1985336 (970 bp)
Type: Others
Protein ID: Protein_2187
Location: 1985646..1985870 (225 bp)
Type: Antitoxin
Protein ID: WP_014511634.1
Location: 1985860..1986252 (393 bp)
Type: Toxin
Protein ID: WP_009993017.1
Location: 1987291..1988343 (1053 bp)
Type: Others
Protein ID: WP_010923271.1
Location: 1982425..1983340 (916 bp)
Type: Others
Protein ID: Protein_2185
Location: 1986695..1987173 (479 bp)
Type: Others
Protein ID: Protein_2190
Location: 1988531..1989118 (588 bp)
Type: Others
Protein ID: Protein_2192
Location: 1989552..1989893 (342 bp)
Type: Others
Protein ID: WP_009990179.1
Location: 1989884..1990231 (348 bp)
Type: Others
Protein ID: WP_014511635.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULG_RS11275 (SULG_11280)1980794..1981924+1131WP_009992604.1aromatic/alkene monooxygenase hydroxylase subunit beta-
SULG_RS11280 (SULG_11285)1981921..1982382+462WP_010923265.1metal-sulfur cluster assembly factor-
SULG_RS11285 (SULG_11290)1982425..1983340-916Protein_2185IS110 family transposase-
SULG_RS11290 (SULG_11295)1983385..1984368+984WP_010923242.1IS630-like element ISC1048 family transposase-
SULG_RS11295 (SULG_11300)1984367..1985336+970Protein_2187IS110 family transposase-
SULG_RS11300 (SULG_11305)1985646..1985870+225WP_014511634.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
SULG_RS11305 (SULG_11310)1985860..1986252+393WP_009993017.1type II toxin-antitoxin system VapC family toxinToxin
SULG_RS11310 (SULG_11315)1986695..1987173-479Protein_2190ISNCY family transposase-
SULG_RS11315 (SULG_11320)1987291..1988343+1053WP_010923271.1ISH3 family transposase-
SULG_RS11320 (SULG_11325)1988531..1989118-588Protein_2192ISNCY family transposase-
SULG_RS11325 (SULG_11330)1989552..1989893-342WP_009990179.1nucleotidyltransferase domain-containing protein-
SULG_RS11330 (SULG_11335)1989884..1990231-348WP_014511635.1HEPN domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1977369..198911811749
-insideIScluster/Tn--1976524..198911812594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-49)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15117.81 Da        Isoelectric Point: 9.3474

>T113428 WP_009993017.1 NZ_CP033235:1985860-1986252 [Saccharolobus solfataricus]
MKDKEFLLDASALYSLLDYVDKVDVKKIHVLTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVIEDSPLEGV
MRIAIERGLTYYNASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T113428 NZ_CP033235:1985860-1986252 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCTTGCTCGATGCCTCAGCTTTGTATTCACTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATGTACTTACCCTAACTTTTTATGAGGTAGGTAATGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCTATAAATTAATGCGAAAATTTAACGTAATAGAGGATTCGCCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATAACGCATCTTATGCGTATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAACGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8792.11 Da        Isoelectric Point: 4.8365

>AT113428 WP_014511634.1 NZ_CP033235:1985646-1985870 [Saccharolobus solfataricus]
MSDVISVRVKKELKKKAEELGINVREVVEKALEEAIREKEKEELKDMTMKIKELMRDVSEDDWVSTVRESRDER

Download         Length: 225 bp

>AT113428 NZ_CP033235:1985646-1985870 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGAGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTAGGAATTAACGTTAGGGAAGT
TGTAGAAAAAGCTTTAGAGGAAGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGACTATGAAAATTAAGGAAC
TAATGAGGGACGTAAGTGAAGATGATTGGGTAAGTACTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3GVD1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3MAZ1

References