113425

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4684305..4684932 Replicon chromosome
Accession NZ_CP033230
Organism Sphingobium yanoikuyae strain SJTF8

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EBF16_RS25925 Protein ID WP_037506113.1
Coordinates 4684305..4684610 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A085KAU2
Locus tag EBF16_RS25930 Protein ID WP_037506112.1
Coordinates 4684645..4684932 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EBF16_RS25905 4679939..4681378 + 1440 WP_037506117.1 porin -
EBF16_RS25910 4681394..4682815 - 1422 WP_037506485.1 carboxylesterase family protein -
EBF16_RS25915 4682985..4683359 - 375 WP_004210471.1 50S ribosomal protein L7/L12 -
EBF16_RS25920 4683432..4683947 - 516 WP_037506115.1 50S ribosomal protein L10 -
EBF16_RS25925 4684305..4684610 + 306 WP_037506113.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EBF16_RS25930 4684645..4684932 + 288 WP_037506112.1 putative addiction module antidote protein Antitoxin
EBF16_RS25935 4684991..4687096 - 2106 WP_004210474.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
EBF16_RS25940 4687218..4687700 + 483 WP_004210475.1 helix-turn-helix transcriptional regulator -
EBF16_RS25945 4687756..4688862 + 1107 WP_004210476.1 histidine kinase -
EBF16_RS25950 4688859..4689662 + 804 WP_004210477.1 LytTR family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-98)

Antitoxin

Uncharacterized protein HI1420

(4-91)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11262.09 Da        Isoelectric Point: 10.7384

>T113425 WP_037506113.1 NZ_CP033230:4684305-4684610 [Sphingobium yanoikuyae]
IYVVGKEVLQTPIFAEWFAALRDRRARSKIAGRIARFELGLLGDVKSVGDGVLEARVDFGPGYRLYFVRRGDRLIVLLVG
GDKSSQPRDIARAKDMAARID

Download         Length: 306 bp

>T113425 NZ_CP033230:4684305-4684610 [Sphingobium yanoikuyae]
ATATATGTTGTCGGCAAGGAAGTGCTGCAAACGCCGATCTTTGCGGAATGGTTCGCCGCGCTTCGCGATCGCCGGGCGCG
GTCGAAGATTGCCGGGCGGATTGCCCGCTTCGAACTGGGATTGCTGGGCGATGTGAAGTCGGTGGGCGATGGCGTGCTAG
AGGCGCGTGTCGATTTCGGTCCGGGCTATCGCCTCTATTTCGTGCGGCGCGGGGATCGGCTGATCGTCCTGCTGGTCGGT
GGCGACAAGTCGAGCCAGCCGCGGGACATCGCCAGGGCAAAGGATATGGCGGCCCGGATCGATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10149.81 Da        Isoelectric Point: 5.6492

>AT113425 WP_037506112.1 NZ_CP033230:4684645-4684932 [Sphingobium yanoikuyae]
MTIELTRFDAAEALTQAEDQAELLADAFATGDVHVITQAIGIVARAHGMTELAKATGMKRQQLYRMLGPDGNPTLGSMLK
LLPALGLRMRIEAAA

Download         Length: 288 bp

>AT113425 NZ_CP033230:4684645-4684932 [Sphingobium yanoikuyae]
ATGACGATCGAATTGACCCGCTTTGATGCGGCTGAGGCGCTGACGCAAGCGGAGGATCAGGCGGAACTGCTCGCCGATGC
GTTCGCCACCGGTGACGTGCATGTCATTACCCAGGCCATCGGGATCGTGGCGCGGGCGCATGGCATGACCGAACTGGCGA
AGGCAACGGGCATGAAGCGCCAGCAACTTTATCGGATGCTCGGCCCCGACGGGAATCCGACGCTGGGCAGCATGCTGAAG
CTGCTGCCGGCGCTGGGGCTGCGGATGCGGATCGAGGCGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085KAU2

References