113417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 680276..680912 Replicon chromosome
Accession NZ_CP033218
Organism Bacillus licheniformis strain TCCC 11148

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag D9Y32_RS03485 Protein ID WP_003179128.1
Coordinates 680276..680626 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag D9Y32_RS03490 Protein ID WP_006638778.1
Coordinates 680631..680912 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9Y32_RS03445 675317..675916 - 600 WP_003179145.1 SpoIIE family protein phosphatase -
D9Y32_RS03450 675913..676704 - 792 WP_003179144.1 RNA polymerase sigma factor SigB -
D9Y32_RS03455 676670..677155 - 486 WP_003179142.1 anti-sigma B factor RsbW -
D9Y32_RS03460 677155..677481 - 327 WP_003179140.1 anti-sigma factor antagonist -
D9Y32_RS03465 677540..678547 - 1008 WP_009330124.1 PP2C family protein-serine/threonine phosphatase -
D9Y32_RS03470 678558..678959 - 402 WP_003179135.1 anti-sigma regulatory factor -
D9Y32_RS03475 678962..679327 - 366 WP_003179132.1 STAS domain-containing protein -
D9Y32_RS03480 679331..680158 - 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
D9Y32_RS03485 680276..680626 - 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
D9Y32_RS03490 680631..680912 - 282 WP_006638778.1 hypothetical protein Antitoxin
D9Y32_RS03495 681024..682193 - 1170 WP_025807384.1 alanine racemase -
D9Y32_RS03500 682418..683377 - 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
D9Y32_RS03505 683720..684319 + 600 WP_003179118.1 rhomboid family intramembrane serine protease -
D9Y32_RS03510 684316..685797 - 1482 WP_142782130.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T113417 WP_003179128.1 NZ_CP033218:c680626-680276 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T113417 NZ_CP033218:c680626-680276 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT113417 WP_006638778.1 NZ_CP033218:c680912-680631 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT113417 NZ_CP033218:c680912-680631 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References