Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1442041..1442556 Replicon chromosome
Accession NZ_CP033200
Organism Micrococcus luteus strain SA211

Toxin (Protein)


Gene name relE Uniprot ID A0A031HZL4
Locus tag FMM_RS06570 Protein ID WP_036316391.1
Coordinates 1442041..1442295 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID D3LMN2
Locus tag FMM_RS06575 Protein ID WP_002855277.1
Coordinates 1442296..1442556 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FMM_RS06540 1437739..1438436 - 698 Protein_1264 aquaporin Z -
FMM_RS06545 1438912..1439145 - 234 Protein_1265 hypothetical protein -
FMM_RS06550 1439383..1440108 + 726 WP_178329127.1 MSMEG_4193 family putative phosphomutase -
FMM_RS06555 1440105..1440647 + 543 WP_036316394.1 DUF3090 domain-containing protein -
FMM_RS06560 1440647..1441429 + 783 WP_036316393.1 SCO1664 family protein -
FMM_RS06565 1441473..1442039 - 567 WP_036316392.1 mismatch-specific DNA-glycosylase -
FMM_RS06570 1442041..1442295 - 255 WP_036316391.1 Txe/YoeB family addiction module toxin Toxin
FMM_RS06575 1442296..1442556 - 261 WP_002855277.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FMM_RS11475 1444564..1446411 - 1848 WP_189338143.1 hypothetical protein -
FMM_RS06585 1446422..1447507 - 1086 WP_122054482.1 redox-regulated ATPase YchF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9943.23 Da        Isoelectric Point: 6.7245

>T113388 WP_036316391.1 NZ_CP033200:c1442295-1442041 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLTRVNTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

>T113388 NZ_CP033200:c1442295-1442041 [Micrococcus luteus]
GTGCGCCTCGTGTGGGACCGCTCCGCCTGGGAGGACTACACGCACTGGCAGACCACGGACCGCAAGGTCCTCACACGGGT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCTTCGAGGGGATCGGCAAGCCCGAGCAGCTGAAGTACGGCGCGGCCG
GGGCATGGTCCCGGCGGATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9579.71 Da        Isoelectric Point: 4.8359

>AT113388 WP_002855277.1 NZ_CP033200:c1442556-1442296 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RLDGDA

Download         Length: 261 bp

>AT113388 NZ_CP033200:c1442556-1442296 [Micrococcus luteus]
ATGTCCATCAGTGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGAATGCGGACCGCGACGCCGTCGA
GATCGTCTCCCGCAAGGGCAACGCCGTTCTCATGCCCGCGGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCCCCGGCCAACGCCCGACGGCTGCTGGACGCCTACGAGCGCGCCCGCGCAGGGAGCGTTGAGGAGCACGCCCTGGAT
CGCCTGGACGGGGACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A031HZL4

Antitoxin

Source ID Structure
AlphaFold DB A0A031HW70

References