Detailed information of TA system TA113376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2790190..2790746
• Replicon: chromosome
• Accession: NZ_CP033194
• Organism: Xanthomonas oryzae pv. oryzae strain CIAT

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EBA18_RS13690
• Protein ID: WP_041182647.1
• Coordinates: 2790190..2790480 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: EBA18_RS13695
• Protein ID: WP_011408759.1
• Coordinates: 2790468..2790746 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA18_RS13640	2786296..2786612	-	317	Protein_2497	ATP-dependent DNA ligase	-
EBA18_RS25270	2786672..2786878	-	207	Protein_2498	hypothetical protein	-
EBA18_RS13650	2786894..2787070	-	177	Protein_2499	DUF3606 domain-containing protein	-
EBA18_RS13655	2787292..2787693	+	402	WP_011259345.1	H-NS histone family protein	-
EBA18_RS13665	2788636..2788637	-	2	WP_094187731.1	IS5 family transposase	-
EBA18_RS13680	2789409..2789588	-	180	WP_015463309.1	hypothetical protein	-
EBA18_RS25545	2789859..2790113	-	255	WP_198912806.1	hypothetical protein	-
EBA18_RS13690	2790190..2790480	-	291	WP_041182647.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EBA18_RS13695	2790468..2790746	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
EBA18_RS25550	2790827..2791030	-	204	WP_198912807.1	hypothetical protein	-
EBA18_RS25555	2790942..2791328	-	387	WP_205421001.1	hypothetical protein	-
EBA18_RS13705	2791231..2791431	-	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
EBA18_RS13710	2792192..2793376	-	1185	WP_133264606.1	IS256 family transposase	-
EBA18_RS13720	2793957..2794922	+	966	WP_109181970.1	IS1595-like element ISXo5 family transposase	-
EBA18_RS13725	2795024..2795629	+	606	Protein_2511	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2788109..2794922	6813

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10929.51 Da
• Isoelectric Point: 9.5554

>T113376 WP_041182647.1 NZ_CP033194:c2790480-2790190 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILALRHQKEAGY

Nucleotide

• Length: 291 bp

>T113376 NZ_CP033194:c2790480-2790190 [Xanthomonas oryzae pv. oryzae]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGG
GATACCGTCACGATTTTGGCCCTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT113376 WP_011408759.1 NZ_CP033194:c2790746-2790468 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT113376 NZ_CP033194:c2790746-2790468 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2