Detailed information of TA system TA113357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2838279..2838835
• Replicon: chromosome
• Accession: NZ_CP033190
• Organism: Xanthomonas oryzae pv. oryzae strain PXO404

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EBA23_RS14125
• Protein ID: WP_027703932.1
• Coordinates: 2838279..2838569 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: EBA23_RS14130
• Protein ID: WP_011408759.1
• Coordinates: 2838557..2838835 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA23_RS14075	2834049..2835140	+	1092	WP_041182166.1	ribonuclease D	-
EBA23_RS14080	2835216..2835553	-	338	Protein_2529	ATP-dependent DNA ligase	-
EBA23_RS24630	2835613..2835819	-	207	Protein_2530	hypothetical protein	-
EBA23_RS14090	2835835..2836011	-	177	Protein_2531	DUF3606 domain-containing protein	-
EBA23_RS14095	2836233..2836634	+	402	WP_011259345.1	H-NS histone family protein	-
EBA23_RS14115	2837498..2837677	-	180	WP_015463309.1	hypothetical protein	-
EBA23_RS24635	2837821..2838018	-	198	WP_004541336.1	hypothetical protein	-
EBA23_RS14125	2838279..2838569	-	291	WP_027703932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EBA23_RS14130	2838557..2838835	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
EBA23_RS24840	2838916..2839119	-	204	WP_199285669.1	hypothetical protein	-
EBA23_RS24845	2839031..2839375	-	345	WP_199285675.1	hypothetical protein	-
EBA23_RS14140	2839320..2839520	-	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
EBA23_RS14145	2840281..2841465	-	1185	WP_011408760.1	IS256 family transposase	-
EBA23_RS14155	2842046..2843011	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
EBA23_RS14160	2843113..2843718	+	606	Protein_2542	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10915.48 Da
• Isoelectric Point: 9.5554

>T113357 WP_027703932.1 NZ_CP033190:c2838569-2838279 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T113357 NZ_CP033190:c2838569-2838279 [Xanthomonas oryzae pv. oryzae]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGG
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT113357 WP_011408759.1 NZ_CP033190:c2838835-2838557 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT113357 NZ_CP033190:c2838835-2838557 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2