Detailed information of TA system TA113353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2833556..2834112
• Replicon: chromosome
• Accession: NZ_CP033189
• Organism: Xanthomonas oryzae pv. oryzae strain PXO421

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EBA24_RS14100
• Protein ID: WP_027703932.1
• Coordinates: 2833556..2833846 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: EBA24_RS14105
• Protein ID: WP_011408759.1
• Coordinates: 2833834..2834112 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA24_RS14050	2829326..2830417	+	1092	WP_041182166.1	ribonuclease D	-
EBA24_RS14055	2830493..2830830	-	338	Protein_2525	ATP-dependent DNA ligase	-
EBA24_RS24590	2830890..2831096	-	207	Protein_2526	hypothetical protein	-
EBA24_RS14065	2831112..2831288	-	177	Protein_2527	DUF3606 domain-containing protein	-
EBA24_RS14070	2831510..2831911	+	402	WP_011259345.1	H-NS histone family protein	-
EBA24_RS14090	2832775..2832954	-	180	WP_015463309.1	hypothetical protein	-
EBA24_RS24595	2833098..2833295	-	198	WP_004541336.1	hypothetical protein	-
EBA24_RS14100	2833556..2833846	-	291	WP_027703932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EBA24_RS14105	2833834..2834112	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
EBA24_RS24820	2834193..2834396	-	204	WP_199285669.1	hypothetical protein	-
EBA24_RS24825	2834308..2834652	-	345	WP_199285675.1	hypothetical protein	-
EBA24_RS14115	2834597..2834797	-	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
EBA24_RS14120	2835558..2836742	-	1185	WP_011408760.1	IS256 family transposase	-
EBA24_RS14130	2837323..2838288	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
EBA24_RS14135	2838390..2838995	+	606	Protein_2538	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10915.48 Da
• Isoelectric Point: 9.5554

>T113353 WP_027703932.1 NZ_CP033189:c2833846-2833556 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T113353 NZ_CP033189:c2833846-2833556 [Xanthomonas oryzae pv. oryzae]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGG
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT113353 WP_011408759.1 NZ_CP033189:c2834112-2833834 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT113353 NZ_CP033189:c2834112-2833834 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2