Detailed information of TA system TA113349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2838178..2838734
• Replicon: chromosome
• Accession: NZ_CP033188
• Organism: Xanthomonas oryzae pv. oryzae strain PXO513

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EBA25_RS14115
• Protein ID: WP_027703932.1
• Coordinates: 2838178..2838468 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: EBA25_RS14120
• Protein ID: WP_011408759.1
• Coordinates: 2838456..2838734 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA25_RS14065	2833948..2835039	+	1092	WP_041182166.1	ribonuclease D	-
EBA25_RS14070	2835115..2835452	-	338	Protein_2533	ATP-dependent DNA ligase	-
EBA25_RS24635	2835512..2835718	-	207	Protein_2534	hypothetical protein	-
EBA25_RS14080	2835734..2835910	-	177	Protein_2535	DUF3606 domain-containing protein	-
EBA25_RS14085	2836132..2836533	+	402	WP_011259345.1	H-NS histone family protein	-
EBA25_RS14105	2837397..2837576	-	180	WP_015463309.1	hypothetical protein	-
EBA25_RS24880	2837720..2837917	-	198	WP_004541336.1	hypothetical protein	-
EBA25_RS14115	2838178..2838468	-	291	WP_027703932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EBA25_RS14120	2838456..2838734	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
EBA25_RS24885	2838815..2839018	-	204	WP_199285669.1	hypothetical protein	-
EBA25_RS24890	2838930..2839274	-	345	WP_199285675.1	hypothetical protein	-
EBA25_RS14130	2839219..2839419	-	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
EBA25_RS14135	2840180..2841364	-	1185	WP_011408760.1	IS256 family transposase	-
EBA25_RS14145	2841945..2842910	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
EBA25_RS14150	2843012..2843617	+	606	Protein_2546	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10915.48 Da
• Isoelectric Point: 9.5554

>T113349 WP_027703932.1 NZ_CP033188:c2838468-2838178 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T113349 NZ_CP033188:c2838468-2838178 [Xanthomonas oryzae pv. oryzae]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGG
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT113349 WP_011408759.1 NZ_CP033188:c2838734-2838456 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT113349 NZ_CP033188:c2838734-2838456 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2