Detailed information of TA system TA113345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2899655..2900211
• Replicon: chromosome
• Accession: NZ_CP033187
• Organism: Xanthomonas oryzae pv. oryzae strain PXO61

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EBA26_RS14470
• Protein ID: WP_027703932.1
• Coordinates: 2899655..2899945 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: EBA26_RS14475
• Protein ID: WP_011408759.1
• Coordinates: 2899933..2900211 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA26_RS14420	2895425..2896516	+	1092	WP_041182166.1	ribonuclease D	-
EBA26_RS14425	2896592..2896929	-	338	Protein_2591	ATP-dependent DNA ligase	-
EBA26_RS24890	2896989..2897195	-	207	Protein_2592	hypothetical protein	-
EBA26_RS14435	2897211..2897387	-	177	Protein_2593	DUF3606 domain-containing protein	-
EBA26_RS14440	2897609..2898010	+	402	WP_011259345.1	H-NS histone family protein	-
EBA26_RS14450	2898335..2898539	-	205	Protein_2595	kfra protein	-
EBA26_RS14460	2898874..2899053	-	180	WP_015463309.1	hypothetical protein	-
EBA26_RS14465	2899324..2899652	-	329	Protein_2597	hypothetical protein	-
EBA26_RS14470	2899655..2899945	-	291	WP_027703932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EBA26_RS14475	2899933..2900211	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
EBA26_RS14480	2900292..2900724	-	433	Protein_2600	relaxase	-
EBA26_RS14485	2900696..2900896	-	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
EBA26_RS14490	2901657..2902841	-	1185	WP_011408760.1	IS256 family transposase	-
EBA26_RS14500	2903422..2904387	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
EBA26_RS14505	2904489..2905094	+	606	Protein_2604	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10915.48 Da
• Isoelectric Point: 9.5554

>T113345 WP_027703932.1 NZ_CP033187:c2899945-2899655 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T113345 NZ_CP033187:c2899945-2899655 [Xanthomonas oryzae pv. oryzae]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGG
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT113345 WP_011408759.1 NZ_CP033187:c2900211-2899933 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT113345 NZ_CP033187:c2900211-2899933 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2